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窒息新生儿血清IL6和IL8水平变化及其临床意义
http://www.100md.com 《滨州医学院学报》 2006年第5期
窒息新生儿；白细胞介素6；白细胞介素8,,窒息新生儿；白细胞介素6；白细胞介素8,1对象与方法,2结果,3讨论,参考文献
     【摘要】 目的 探讨外周血白细胞分素8(IL8)在窒息新生儿中的变化及临床意义。方法 采用ELISA法检测42例不同程度窒息新生儿不同病期血清的IL6、IL8水平，并与正常足月新生儿脐血42例进行对照。结果 窒息新生儿第1天血清IL6为576 ng/L(中位数，以下同)，IL8为3533 ng/L，明显高于正常脐血对照组的20、92 ng/L(Z=4564~5856，P<001)。重度窒息组患儿血清IL6、IL8分别是87、5796 ng/L，分别高于轻度组(526、3363 ng/L)(Z=2228~2702，P<005)。血清IL6、IL8水平间呈显著正相关(α=059~072，P<001)。窒息组患儿动态观察发现，病程第3天时血清IL6(566 ng/L)、IL8(3206 ng/L)水平较第1天时(分别为576、3533 ng/L)差异均无显著性(Z=0314~1372，P<005)；第7天时血清IL6(146 ng/L)、IL8(2384 ng/L)水平均明显低于第1天和第3天时(Z=2455，P<005，Z=3622，P<001)。结论 窒息新生儿血清中IL6、IL8水平明显增高，在新生儿窒息发病机制中起重要作用。

    【关键词】 窒息新生儿；白细胞介素6；白细胞介素8

    Change of IL6 and IL8 in asphyxia newborn and clinical significance

    WANG Guoliang GAO Yanling ZHAO Guohua

    Department of Pediatrics,People's Hospital of Dezhou,Dezhou,253014

    【Abstract】 Objective To explore the change of IL6 and IL8 in asphyxia newborn and clinical significance.Methods Compared with the control group,ELISA method was used to determine the degree of IL6 and IL8 in different asphyxia newborn and in different coures of diseaseResults In asphyxia newborn group serum IL6(576 ng/L)and IL8(3533 ng/L)were higher than the control group(20,92 ng/L)(Z=4564~5856,P<001)in the first day,heavy asphyxia group serum IL6(87 ng/L)and IL8(5796 ng/L)were higher than light asphyxia group(526,3363 ng/L)(Z=2228~2702,P<005)and had obviously positive correlation(a=059~072,P<001)Serum IL6(566 ng/L) and IL8(3206 ng/L) did not have obviously difference compared with the first day on the third day(Z=0314~1372,P<005);serum IL6(146 ng/L) and IL8(2384 ng/L) were lower than aboues on the seventh day (Z=2455,P<005,Z=3622,P<001)Conclusion Serum IL6 and IL8 degree improved apparently in asphyxia newborn which had important value in newborn asphyxia pathogenesis. ......

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