【摘要】目的探讨发作性睡病与HLA-DRB1基因的相关性。方法30例患者经系统的病史询问、查体、多次小睡潜伏时间试验测试(MSLT)等方法诊断为发作性睡病。用序列特异性引物-聚合酶链反应(PCR-SSP)分型技术，对30例发作性睡病患者和44例健康人进行HLA-DRB1等位基因的检测。结果发作性睡病患者组DRB1*15出现频率为53.33%，与正常对照组13.64%相比较明显增高，经统计学分析差异有显著性(P<0.05)。结论HLA-DRB1*15基因为中国发作性睡病人群的易感基因。

    【关键词】发作性睡病；HLA基因；易感性

    Study on the association between HLA-DRB1*15 genes and narcolepsy

    JIANG Tian-shu，ZHOU Ye，CHEN Yan，et al.Laboratory Diagnostics，Changzheng Hospital，Second Military Medical University，and Clinical Immunology Center of PLA，Shanghai 200003，China

    【Abstract】ObjectiveTo investigate the association between HLA-DRB1 genes and narcolepsy.MethodsHLA typing were performed in 30 patients with narcolepsy by HLA-DRB1 resolution PCR-SSP(sequence specific primers)，then the frequencies of alleles were analyzed compared with normal controls.ResultsThe frequencies of DRB1*15 in narcolepsy were significantly higher than normal controls(53.33% versus 13.64%).ConclusionDRB1*15 was susceptible gene for narcolepsy.

    【Key words】narcolepsy；HLA gene；susceptibility

    发作性睡病(narcolepsy)是一种病因不明的慢性神经系统疾病 ......