【摘要】 14-3-3是一个在真核生物中广泛表达的酸性蛋白家族，主要以同源/异源二聚体形式存在，通过磷酸化丝/苏氨酸作用与靶蛋白或靶蛋白的两个结构域结合。七种不同亚型的高度保守的14-3-3蛋白与人类细胞中多种不同的信号通路有着密切的关系。14-3-3通过调节靶蛋白间的相互作用在MAPK级联放大效应等信号转导途径中发挥调控作用。

    【关键词】 14-3-3；二聚体；蛋白磷酸化；蛋白质相互作用；信号转导

    14-3-3 proteins

    PAN Wei-nan，CHEN Lin-xi，et al.

    Institute of Pharmacy & Pharmacology，Nanhua University，Hengyang，Hunan 421001，China

    【Abstract】 The 14-3-3 proteins are a family of abundant，widely expressed acidic polypeptides in all eukaryocytic cells，which act mainly as either homodimers or heterodimers.The 14-3-3 proteins interact with targeting proteins or two different domains in one targeting protein by phosphoserine/phosphothreonine motifs.Seven different，but highly conserved 14-3-3 proteins are involved in diverse signaling pathways in human cells.14-3-3 plays a role in controlling interaction with targeting proteins through the MAPK signaling cascade etc.cell signal transduction pathways.

    【Key words】 14-3-3；dimer；targeting proteins phosphorylation；protein-protein interaction；signal transduction

    14-3-3是一个丰富的广泛表达的蛋白家族，是一个可以自发聚集成二聚体的多功能蛋白质 ......