动脉化疗对进展期胃癌CEA mRNA及CK19 mRNA表达的影响
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张 强, 姚惠香, 孙 群, 朱金水
胃肿瘤;逆转录聚合酶链反应;角蛋白19;癌胚抗原;介入化疗;放疗,动脉化疗对进展期胃癌CEAmRNA及CK19mRNA表达的影响,张强,姚惠香,孙群,朱金水,通讯作者:,Effectsofarte
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张强, 姚惠香, 孙群, 朱金水, 上海交通大学附属第六人民医院消化科 上海市 200233
通讯作者: 朱金水, 200233, 上海市宜山路600号, 上海交通大学附属第六人民医院消化科. zhujs1803@hotmail.com
电话: 021-64369181-8969 传真：021-64837019
收稿日期: 2006-08-26 接受日期: 2006-09-15
Effects of artery intervention chemotherapy on mRNA expression of carcinoembryonic antigen and cytokeratin 19 in progressive gastric cancer
Qiang Zhang, Hui-Xiang Yao, Qun Sun, Jin-Shui Zhu
Qiang Zhang, Hui-Xiang Yao, Qun Sun, Jin-Shui Zhu,Department of Gastroenterology, the Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
Correspondence to:Jin-Shui Zhu, Department of Gastroenterology, the Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China. zhujs1803@hotmail.com
Received:2006-08-26 Accepted:2006-09-15
Abstract
AIM: To explore the values of carcinoembryonic antigen (CEA) and cytokeratin 19 (CK19) mRNA expression in the evaluation of artery intervention chemotherapy for progressive gastric cancer.
METHODS: A total of 30 gastric patients (n = 3, 15, and 12, respectively, for stage Ⅱ, Ⅲ, and Ⅳ) were included in this study. Peripheral blood samples were collected 2-3 d before and 2-3 wk after EAP interventional chemotherapy. Automated immunoassay was used to measure the level of serum CEA and tissue polypeptide antigen (TPA), and reverse transcription-polymerase chain reaction was performed to detect the expression of CEA and CK19 mRNA. Endoscopic ultrasound (EUS) combined with computed tomography (CT) was applied to assess the efficacy of chemotherapy.
RESULTS: The expression of CEA and CK19 mRNA in peripheral blood cells were significantly different before and after interventional chemotherapy [CEA: 60.0% (18/30) vs 33.3% (10/30), χ2 = 4.29, P < 0.05; CK19: 73.3% (22/30) vs 46.7% (14/30), χ2 = 4.34, P < 0.05]. The positive rate of CEA and CK19 mRNA combined detection was also markedly different before and after chemotherapy [90 ......
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