YIN Cao1, SHEN Liª²Jia2, XIE Siª²Ming2, XIE Liª²Qun2

    1Department of Oral Mucosal Diseases, Stomatological Hospital of Guangdong Province£¬Guangzhou 510280£¬China, 2Department of Stomatology, Medical College, Jinan University, Guangzhou 510632, China

    ¡¾Abstract¡¿ AIM: To detect the expression of heat shock protein 70, 90 (HSP 70, HSP 90) in oral squamous cell carcinoma (OSCC) and oral precancerous lesions and investigate the roles of HSP 70 and HSP 90. METHODS: SABC immunohistochemical methods were used to detect the expressions of HSP 70 and HSP 90 in 42 cases of OSCC, 22 cases of oral lichen planus(OLP), 20 cases of oral leukoplakia and 10 cases of normal oral mucosa. RESULTS: The rate of the positive or high expression of HSP70 in OLP was 91% (20/22), which was remarkably higher than those of normal oral mucosa, oral leukoplakia and OSCC (P<0.05). The rates of positive or low expression of HSP90 in OLP and OSCC were 73%(16/22) and 70%(14/20), respectively, which was significantly higher than those of oral normal mucosa and oral leukoplakia(P<0.05). CONCLUSION: Both HSP70 and HSP90 may play a role in oral lichen planus. HSP90 may be related with the pathogenesis of OSCC. ......