Biological security evaluation of an absorbable CPP material

    YANG Tuanª²Min, ZHANG Qingª²Hua, XUE Jinª²Shan, HE Zengª²Liang, LI Yi, JIAO Ning, ZHANG Wen

    1Department of Orthopaedics, Xi¬ðan Red Cross Hospital, Xi¬ðan 710054, China

    2Beihuan Hospital, Xi¬ðan 710032, China

    ¡¾Abstract¡¿ AIM: To evaluate the biological security of a new kind of absorbable CPP material used for internal fixation of fracture. METHODS: Maximal tolerant dose of CPP was determined by intraperitoneal (ip) injection of its extractives to mice, and micronucleus test of bone marrow cells, spermatic aberration test, chromosomal aberration test, and teratogenic test were done by ip injection of maximal tolerant dose of CPP to evaluate its biological security. CPP intramuscular implantation was performed to observe its surrounding tissue reaction and evaluate its biological compatibility. RESULTS: Maximal tolerant dose of CPP extractives was above 40 mL/kg, and this dose did not have any obvious effects on micronucleus rate of bone marrow cells (1.36¡À0.27)¡ë, chromosomal aberration rate (1.94¡À0.46)%, spermatic aberration rate (1.51¡À0.37)% and teratogenic rate (1.84¡À0.55)% when compared with controls. CPP intramuscular implantation also did not cause obvious surrounding tissue inflammatory reaction. CONCLUSION: CPP is a new safe medical material with good tissue compatibility. ......