肺癌；双重化疗；肺动脉；手术____

肺动脉与支气管动脉双重插管化疗后 II期手术切除中晚期肺癌

http://www.100md.com 《东南国防医药》 2006年第5期

肺癌；双重化疗；肺动脉；手术,,],肺癌；双重化疗；肺动脉；手术,肺动脉与支气管动脉双重插管化疗后II期手术切除中晚期肺癌,1资料和方法,2结果,3讨论,参考文献

     [摘要] 目的观察肺癌患者行肺动脉与支气管动脉双重插管化疗(DAI)肿瘤缓解后行II期手术切除治疗的疗效。方法 78例肺癌患者行肺动脉与支气管动脉双重插管化疗，18例行手术治疗，有16例行肺叶或全肺切除肿瘤和纵隔淋巴结。结果 78例中DAI总有效率达91%，肺癌肿瘤区的肿瘤中心出现不同程度的坏死，坏死程度与肿瘤区血管染色呈正相关，16例中有8例肿瘤坏死程度达90%，坏死程度>50%有3例，另有5例坏死<50%。术后1、3、5年生存率为67%，50%，38%。其中有4例患者已存活10年。结论肺动脉参与肺癌组织的供血，行肺动脉与支气管动脉双重插管化疗后肿瘤发生以中心坏死为主的反应，可以使部分肿瘤得到根治切除，提高手术疗效及患者存活率。

    [关键词] 肺癌；双重化疗；肺动脉；手术

    Resection of middleadvanced stage lung cancer following percutaneous bronchial and pulmonary artery dual infusion intervention therapy

    YE Fulin1, ZHANG Yujing1,GAO Congjing2,SHI Yue2, FANG Yuqing1,WANG Zexin1,YANG Yinyu1 (1Department of Thoracic Surgery；2Department of Radiology, the 97th Hospital of PLA, Xuzhou 221004, Jiangsu, China)

    [Abstract] Objective To discuss the secondary surgery effects of lung cancer following percutaneous bronchial and pulmonary artery dual infusion intervention therapy(DAI)Methods DAI were performed in 78 patients, 16 of them were underwent pneumonectomy or lobectomy plus nodal of mediastinum removalResults The total remission rate of 78 patients was 91%, and different degrees of necrosises were found in the center of cancer tissues, which presented positive corresponding with vessel staining among cancer tissues The degree of necrosis was above 90% in 8 of the 16 cases; above 50% in 3;less than 50% in 5 cases, and the 1, 3, 5year survival rates were 67% ......

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