LIU Suª²Rong, WANG Min, WU Xiª²Li£¬ GAO Yanª²Qiong

    Department of Integrated Chinese Traditional and Western Medicine, Second Affiliated Hospital, Medical College, Xi¬ðan Jiaotong University£¬ Xi¬ðan 710061, China

    ¡¾Abstract¡¿ AIM: To investigate the neuroprotective mechanism of Funao decoction in the treatment of repeated cerebral ischemia/reperfusion injury. METHODS: Totally 70 mice were randomly divided into 7 groups of 10 mice each: blank control group, sham operated groups of 1 and 10 d, model groups of 1 and 10 d, herb groups of 1 and 10 d (Funao decoction). The mice in the herb groups were perfused gastrically with Funao decoction, while those in the other groups with distilled water, both followed by cerebral ischemia/reperfusion 5 d later. One or 10 d after operation, the brains were taken following rapid decapitation to measure the activity of superoxide dismutase (SOD) and the contents of malondialdehyde (MDA), tumor necrosis factorª²¦Á (TNFª²¦Á) and interleukinª²1¦Â (ILª²1¦Â). RESULTS: The activities of SOD were significantly reduced to (13.95¡À4.52) mg/g and (15.82¡À4.39) mg/g respectively at 1 and 10 d after cerebral ischemia/reperfusion, as compared with the control group [(26.82¡À3.58) mg/g]; while the contents of MDA, TNFª²¦Á and ILª²1¦Â were significantly increased. In comparison with the model group, Funao decoction was effective to increase the activity of SOD [(21.35¡À4.07) mg/g, F=16.56, Q=3.29, P<0.05] and decrease the contents of MDA (F=81.88, Q=34.61 ......