胰岛素抗药性；糖维康；瘦素；TNFα；C肽_

糖维康对胰岛素抵抗大鼠瘦素、TNFα及C肽水平的影响

http://www.100md.com 《第四军医大学学报》 2006年第17期

胰岛素抗药性；糖维康；瘦素；TNFα；C肽,,胰岛素抗药性；糖维康；瘦素；TNFα；C肽,0引言,1材料和方法,2结果,3讨论,【参

     Effect of Tangweikang on leptin, TNFα and Cpeptide in rats with insulin resistance

    JIN ShaoJu, JIANG YuanXu, HU XuZhen, LIU Jun

    1Department of Pharmacology, Ningxia Medical College, Yinchuan 750004, China

    2Department of Endocrinology, Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan 750001, China

    【Abstract】 AIM: To study the effect of Tangweikang on blood glucose, serum insulin, leptin, TNFα and Cpeptide in rats with insulin resistance (IR). METHODS: The IR rats were induced by administration of highfat and highsugar diet. At the same time, the different dose of Tangweikang was given to the rats. After 10 weeks, the blood glucose was tested by the glucose oxidase method and serum insulin, leptin, TNFα and Cpeptide were determined by radioimmunoassay in the rats. RESULTS: Tangweikang 1.5 g/mL, 0.75 g/mL increased the IR rats insulin sensitivity index (ISI) (P<0.01), decreased serum leptin (P<0.05). Combining Tangweikang 1.5 g/mL and Metformin 104 mg/kg decreased the levels of serum leptin and TNFα (P<0.01), and increased Cpeptide (P<0.05) in IR rats. Tangweikang 0.75 g/mL increased IR rats Cpeptide level (P<0.05). CONCLUSION: Tangweikang can improve ISI of IR rats, by decreasing serum leptin, enhancing Mets effect to reduce the level of serum TNFα and increasing Cpeptide. ......

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