呼吸道感染;_铜绿假单胞菌;_抗生素联合;

头孢哌酮、头孢他啶和左氧氟沙星联用对呼吸道感染铜绿假单胞菌抗菌活性的研究

http://www.100md.com 《河北北方学院学报》 2006年第3期

呼吸道感染;,铜绿假单胞菌;,抗生素联合;,头孢哌酮;,头孢他啶;,左氧氟沙星,,呼吸道感染;,铜绿假单胞菌;,抗生素联合;,头孢哌酮;,头孢他啶;,左氧氟沙星,头孢哌酮、头孢他啶和左氧氟沙星联

     【摘要】目的:评价头孢哌酮、头孢他啶与左氧氟沙星对呼吸道分离的铜绿假单胞菌体外联合效应，为临床用药提供实验依据。方法: 用微量液体稀释法测三种抗生素单用时对31株铜绿假单胞菌的最低抑菌浓度(MIC)，并用微量液体平板棋盘法测出联合用药时对这些菌株的MIC，计算FIC指数。结果：头孢哌酮、头孢他啶和左氧氟沙星联合用药对铜绿假单胞菌的体外抗菌协同作用为355%～387%,相加作用为419%～452%，无关作用为161%～226%,无拮抗效应。结论：头孢哌酮、头孢他啶和左氧氟沙星联合应用，对呼吸道分离的铜绿假单胞菌的体外抗菌作用以协同和相加作用为主，无拮抗效应。

    【关键词】呼吸道感染; 铜绿假单胞菌; 抗生素联合; 头孢哌酮; 头孢他啶; 左氧氟沙星

    Study on the Combination of Cefoperazone or Ceftazidime with Levofloxacin Against

    Pseudomonas Aeruginosa in Respiratory Tract Infection and in the Vitro Activities

    WEN Cuiling, ZHANG Zhihua, ZHANG Xiulong

    Department of Respirology,The First Affiliated Hospital,

    Hebei North University, Zhangjiakou, 075000, Hebei China

    【ABSTRACT】 Objective: To estimate the combination effect of cefoperazone, ceftazidime with levofloxacin in vitro, and provide experimental data for clinical practice. Methods: Minimum inhibitory concentration(MIC)values of three antibiotics were determined in Mueller Hinton broth by the microdilution technique.MICs of the combination of cefoperazone or ceftazidime and levofloxacin were determined by the microdilution chequer boardtechnique,interpretation of the results was made by calculation of FIC. Results: The results of combining cefoperazone or ceftazidime with levofloxacin showed that synergy was found 355%~387%, addition was 419%~452%, indifference was 161%~226%, none of the combination had an antagonistic effect. Conclusion: The results suggested that synergism and additivity of cefoperazone or ceftazidime with levofloxacin respectively against PA which caused respiratory tract infection should be main action, there was no antagonism. ......

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