【摘要】 损伤时间推断，一直是法医病理学领域中研究的重要课题。为了寻找准确推断损伤时间的方法，本文综述了巨噬细胞在损伤修复过程中的作用机理、伤后巨噬细胞源性细胞因子的表达和巨噬细胞吞噬物的演化与损伤时间的关系。认为进一步研究巨噬细胞在损伤修复中的特征性变化，有望成为推断损伤时间的新方法之一。

    【关键词】 法医病理学；巨噬细胞；损伤修复；损伤时间推断

    The role of macrophages in wound age estimation during the wound healing process

    LOU Xu-peng, XU Xiao-ming, GONG Zhi-qiang.The Forensic Department in Medical College of Nanchang University, Nanchang,Jiangxi 330006,China

    【Abstract】 Dating of injures is always an important hot topic in the field of forensic medicine. To seek a method to estimate exact dating of injury, this article reviewed the mechanism of macrophage during the repair of injury, the expression of cytokines derived from macrophages after injury and the relation between the changes of phagosomes in macrophages and the dating of injury. It is suggested that some characteristic changes of macrophage during the repair of injury could be one of new ways for dating of injures.

    【Key words】 forensic pathology; macrophage ；repair of injures；wound age estimation

    为了寻找准确推断损伤时间的方法，现把巨噬细胞在损伤时间推断中的作用综述如下。

     1 损伤修复的病理生理学概况 ......