【摘要】 目的 探讨经引流管125I粒子植入治疗恶性胆管狭窄的初步临床价值。方法 6例胆管恶性狭窄病例，先行经皮肝穿胆道引流，向狭窄胆管内置入金属内支架，再通过18G穿刺针向引流管内的塑料软管植入125I粒子。结果 6例患者术中共植入125I粒子64枚，手术均顺利完成。术中未发生碘籽缺失，没有观察到急性放射污染的病例。术后随访12个月，一年生存率50%，无严重并发症。结论 经引流管植入125I粒子治疗恶性胆管狭窄，具有方法简便，防护简单，近期疗效好，肿瘤组织受辐照肯定，正常组织放射损伤小，相关并发症少等优点。

    【关键词】 125I粒子；恶性胆管狭窄；胆管内置入金属内支架

    The study of treating malignant biliary obstruction with implantation of permanent 125I seeds by biliary tract drainage

    CAO Jun, SHEN Jun-kang, JIN Yi-qi, et al.Dahua Hospital,Shanghai 200237, China

    【Abstract】 Objective To evaluate the clinical significance of treating malignant biliary obstruction with implantation of permanent 125I seeds by biliary tract drainage.Methods We implanted total 6 stents via percutaneous transhepatic in 6 patients with malignant biliary obstruction , then implanted 125I seeds to the plastic soft tube in the biliary tract drainage through 18G needle. Results The number of 125I seeds implanting in 6 cases was 64,all cases was succeed, and followed - up for 12 months, the 1-year survival rate was 50%. No severe syndrome occurred. Conclusion The treating malignant biliary obstruction with implantation of permanent 125I seeds through biliary tract drainage may be simple in method and protection ,effective in the near future. Further more, it is sure in the tumor organization by radiation, less effect in the normal organization, few in complication. ......