血小板减少性紫癜44例临床分析
血小板减少性紫癜；病毒感染；治疗方法,,],血小板减少性紫癜；病毒感染；治疗方法,1资料与方法,2结果,3讨论
[摘要] 目的 总结小儿血小板减少性紫癜(ITP)的临床特点，及其发生与病毒感染的关系及治疗。方法 对44例ITP患者的临床资料进行回顾性分析。结果 急性血小板减少性紫癜占68.2%，慢性血小板减少性紫癜占31.8%；男女比例为1.75∶1；PAIgG升高占75%，PAIgA升高占5%；发病1～6周前有明确前驱感染者24例(54.5%)；检测到巨细胞病毒(CMV)、EB病毒(EBV)、人微小病毒B19感染急性病例5例(16.7%)，慢性病例11例(78.6%)；在传统治疗方法外，采用更昔洛韦(丽科伟)、膦甲酸钠(可耐)清除病毒感染，急性患者全部治愈，慢性患者疗效提高。结论 血小板减少性紫癜，特别是慢性病例的发生与病毒感染密切相关；采用更昔洛韦、膦甲酸钠清除病毒，可提高疗效。[关键词] 血小板减少性紫癜；病毒感染；治疗方法
Clinical analysis of 44 cases of idiopathic thrombocytopenia purpura
MA Jinwen.The Second People’s Hospital of Hanchuan,Hanchuan 431616,China
[Abstract] Objective To study the clinical features of children idiopathic thrombocytopenia purpura (ITP) and its association with virus infection.Methods The clinical data of 44 cases of ITP was retrospectively analyzed.Results The incidence of acute cases was 68.2%,and the chronic ones was 31.8%.The incidence between male and female was 1.75∶1.The elevated level of PAIgG was found in 75% patients,and PAIgA was in 5%.The occurance of preliminary infecion was found in 24 cases (54.4%),1～6 weeks before ITP was diagnosed.5 of the acute patients (16.7%) had infections of cytomegalovirus,EB virus or human parvovirus B19,and the data of chronic patients was 11 cases (78.6%).Besides the ordinary treatment,ganciclovir and foscarnet sodium were used to clear the viruses.The acute patients were all cured,and the cure rate of chronic group was elevated.Conclusion ITP especially chronic cases was associated with the infection of virus,ganciclovir and foscarnet sodium have efficacy for treatment of ITP with virus infection. ......
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