促结肠动力中药筛选及其机制
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衣兰娟, 田 琳, 梁宁霞, 魏睦新
中药;胃肠动力;平滑肌;结肠;豚鼠衣兰娟,田琳,梁宁霞,魏睦新.促结肠动力中药筛选及其机制. 世界华人消化杂志2006;14(32)3093-3097 各中药对结肠平滑肌收缩作
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衣兰娟, 田琳, 梁宁霞, 魏睦新, 南京医科大学第一附属医院中医科 江苏省南京市 210029
衣兰娟, 2002年山东中医药大学学士, 南京医科大学硕士研究生在读, 住院医师, 主要从事胃肠动力方面研究.
江苏省“135”工程重点人才项目, No. RC2002049
通讯作者: 魏睦新, 210029, 江苏省南京市广州路300号, 南京医科大学第一附属医院中医科. yilanjuanhj@163.com
电话: 025-83716602 传真: 025-83716602
收稿日期: 2006-07-04 接受日期: 2006-07-31
Selection of Chinese medicine with procontractile activity on colonic muscle and its mechanism
Lan-Juan Yi, Lin Tian, Ning-Xia Liang, Mu-Xin Wei
Lan-Juan Yi, Lin Tian, Ning-Xia Liang, Mu-Xin Wei, Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Supported by the Key Talent Foundation of the “135” Project from the Government of Jiangsu Province, No. RC2002049
Correspondence to: Dr. Mu-Xin Wei, Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. yilanjuanhj@163.com
Received: 2006-07-04 Accepted: 2006-07-31
Abstract
AIM: To determine the procontractile activity of six Chinese herbal medicines, including Rhizoma Atractylodis Macrocephalae (RAM), Fructus Foeniculi (FF), Herba Taraxaci (HT), Semen Raphani (SR), Pericarpium Arecae (PA) and Rhizoma Curcumae (RC) on the colonic muscle strips isolated from guinea pigs, and study the possible mechanisms.
METHODS: The colonic longitudinal muscle strips of guinea pigs were prepared. Sodium chloride (9 g/L) and acetylcholine were used in the controls. The effects of six Chinese herbal medicines (RAM, FF, HT, SR, PA, RC) and the control medicine on the contraction of isolated colonic strips from guinea pigs were observed. The results were expressed with contraction amplitude (g), contraction time, and area under curves (AUC, g·s), and the maximal wave height was analyzed 5 min within the addition of drugs ......
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