实验性急性肝内胆汁淤积幼年大鼠胃肠消化间期移行性肌电复合波的变化
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胡玉莲, 王晓东, 黄志华
肝内胆汁淤积;消化间期;移行性肌电复合波;胆汁流量胡玉莲,王晓东,黄志华.实验性急性肝内胆汁淤积幼年大鼠胃肠消化间期移行性肌电复合波的变化. 世界华人消化杂志2006;14(32)3098
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胡玉莲, 王晓东, 黄志华, 华中科技大学同济医学院附属同济医院儿科 湖北省武汉市 430030
胡玉莲, 在读博士, 主要从事儿科消化系统疾病研究.
通讯作者: 黄志华, 430030, 湖北省武汉市, 华中科技大学同济医学院附属同济医院儿科. zhhuang@tjh.tjmu.edu.cn
电话: 027-88067030
收稿日期: 2006-07-23 接受日期: 2006-09-28
Changes of gastrointestinal interdigestive migrating myoelectric complex in rat intrahepatic cholestasis induced by alpha-naphthyl-isothiocyanate
Yu-Lian Hu, Xiao-Dong Wang, Zhi-Hua Huang
Yu-Lian Hu, Xiao-Dong Wang, Zhi-Hua Huang, Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to: Zhi-Hua Huang, Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. zhhuang@tjh.tjmu.edu.cn
Received: 2006-07-23 Accepted: 2006-09-28
Abstract
AIM: To investigate the changes of gastro-intestinal interdigestive migrating myoelectric complex (MMC) in the weaned rat models of acute intrahepatic cholestasis induced by alpha-naphthyl-isothiocyanate (ANIT).
METHODS: A total of 56 weaned Sprague Dawley rats were randomly divided into two groups: control group (n = 16) and toxication group (n = 40). Three pairs of bipolar silver electrodes were chronically implanted in the antrum, duodenum and jejunum of 8 rats from each group in random. Sham operation was performed in the other rats of both groups. Seven to ten days after the operation, MMC was recorded in all the rats with implanted electrodes. Then, all of the rats in toxication group received a single intragastric administration of ANIT (200 mg/kg) in order to induce acute intrahepatic cholestasis. The gastrointestinal MMC was recorded in conscious and fasting status 48, 96, 144, 192 h after ANIT was given. The levels of biliary flow, total bilirubin (TB) and alanine aminotransferase (ALT) were recorded at the same time ......
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