蠲痹膏及其配伍方治疗寒湿型强直性脊柱炎的临床研究
方剂配伍；,外治法；,强直性脊柱炎；,寒湿证,1资料与方法,2结果,3讨论,参考文献:
摘要: 目的：探讨蠲痹膏及其配伍方硬膏治疗寒湿型强直性脊柱炎的疗效及其药物配伍的作用。方法：按照祛风寒湿药物和活血止痛通络药物一定比例制作出蠲痹膏，另制作出以蠲痹膏中祛风寒湿药物为主的配伍方硬膏(不含活血通络止痛药物)。将入选的61例患者随机分为蠲痹膏组、配伍方硬膏组和常规治疗组。常规治疗组口服柳氮磺吡啶，蠲痹膏组与配伍方硬膏组分别在口服柳氮磺吡啶的基础上加用蠲痹膏与配伍方硬膏贴敷治疗。观察指标为下腰背痛评分、Bath疾病活动性指数(BASDAI)、Bath功能指数(BASFI)、晨僵时间、指地距、Schober试验、血沉、C反应蛋白及总有效率。结果：3组总有效率分别为63.64%、52.63%、42.11%，差异无统计学意义(P>0.05)。下腰背痛评分、指地距蠲痹膏组分别与配伍方硬膏组和常规治疗组比较，差异均有统计学意义(P<0.05)，配伍方硬膏组和常规治疗组差异无统计学意义(P>0.05)。BASDAI蠲痹膏组、配伍方硬膏组与常规治疗组比较差异均有统计学意义(P<0.05)，蠲痹膏组与配伍方硬膏组差异无统计学意义(P>0.05)。各组消化道副反应发生率差异无统计学意义(P>0.05)，蠲痹膏组及配伍方硬膏组皮肤搔痒症状与常规治疗组差异有统计学意义(P<0.05)。结论：蠲痹膏及其配伍方硬膏均能改善寒湿型强直性脊柱炎疾病活动指数，优于单用柳氮磺吡啶治疗。活血止痛通络药物配伍到蠲痹膏可缓解寒湿型强直性脊柱炎下腰背痛及指地距。主题词： 方剂配伍； 外治法； 强直性脊柱炎； 寒湿证
Clinical study on Juan Bi Gao and its decomposed recipe for treatment of ankylosing spondilitis of colddampness sydrome
WU Di, MA Chen, LI Qing, et al
(Department of Rheumaology, TCM Affiliated Hospital, Xinjiang Medical University,Urumqi 830000, China)
Abstract: Objective： To investigate the clinical effect and safety of Juan Bi Gao (JBG) on the treatment of ankylosing spondylitis (AS) of colddampness syndrome, meanwhile, to explore prescription compatibility through comparing the therapeutic character of JBG with its partial herbs′ compatible prescription called Qu Feng Han Shi Gao (QFHSG). Methods： Sixtyone cases were randomly divided into three groups：JBG sticking treatment group (group JBG), QFHSG sticking treatment group(group QFHSG) and a control group (only treated with SASP 500 mg t.i.d) and twentytwo cases for group JBG, twenty cases for group QFHSG, nineteen cases for control group. Aside from external drugs, group JBG and group QFHSG received the same treatment as in control groups. The treatment lasted one month, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Function Index (BASFI), score on the pain of lower waist and back, Schober test, time of morning stiffness, distance of middlefinger to floor, ESR, CRP were observed and measured before and after treatment. Results：The total effective rate of group JBG, group QFSHG and control group were 63.64%, 52.63% ......
您现在查看是摘要页，全文长 13739 字符。