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    Effect and Significance of ª­ª©dbcªªAMP-Ca on Pituitary Ade nylate Cyclase Activiting Poly-peptide and Vasoactive Intestinal Peptide in Plasma and Stomach Organization of Rat with Gastric Stress Ulcers Induced by Internal Capsule Hemorrhageª§

    Lin Hansheng,et al.ª§

    (Department of General Surgery,People¡¯s Hospital of Taiping,Dongguan,Guangdong,523900)ª¥

    ¡¾Abstract¡¿ Objective To investigate therapeutic effects and mechanism of ª­ª©dbcªªAMP-Ca in treatment of rat with gastric stress ulcers induced by internal capsule hemorrhage. Methods The levels of Pituitary Ade nylate Cyclase Activiting Poly-peptide (PACAP) and Vasoactive intestinal peptide (VIP) in plasma and stomach organization of rat with Cerebral hemorrhage and treated by ª­ª©dbcªªAMP-Ca after 24h were determined by RIA. Results The levels of PACAP and VIP in plasma of Cerebral hemorrhage group was significantly higher than that in control groupª§(P<ª§0.01).and the levels of PACAP and VIP in stomach organizes of Cerebral hemorrhage group was lower than that in control groupª§(P<ª§0.01). The levels of PACAP and VIP in plasma of treatment group was significantly lower than that in Cerebral hemorrhage groupª§(P<ª§0.01),and the levels of PACAP and VIP in stomach organizes of treatment group was higher than that in Cerebral hemorrhage group ª§(P<ª§0.01). Conclusions PACAP and VIP may play an important role in gastric stress ulcers induced by internal capsule hemorrhage,ª­ª©dbcªªAMP-Ca have an important effect on treatment of rat with gastric stress ulcers induced by internal capsule hemorrhage. ......