[摘要] 目的 探讨血清胎盘生长因子(PLGF)水平和子宫动脉血流动力学变化对妊娠结局的影响。方法 2005年3月～2006年4月共收集我院162例孕妇资料，孕10～14周时抽取孕妇外周血，ELISA测定PLGF水平；孕20～24周开始，采用多普勒彩超监测两侧子宫动脉的收缩期峰值、舒张期最低流速之比(S/D)、阻力指数(RI)、搏动指数(PI)；随访至产后3个月，统计孕妇和新生儿转归。结果 发生妊娠期高血压疾病的患者，血清PLGF为(36.2±8.3) pg/ml，明显低于正常组(52.9±9.6) pg/ml(P<0.01)。S/D值、RI、PI、舒张早期切迹等指标差异亦有显著性(P<0.05)。血流指标异常的孕妇，妊娠并发症率和胎儿死亡率显著升高(P<0.05)，新生儿结局较差(P<0.05)。结论 PLGF表达异常和血流动力学变化，与妊娠期并发症和新生儿不良转归有密切联系，可以作为临床监测指标，以利于及时预防、治疗和改善预后。

    [关键词] 彩色多普勒超声；胎盘生长因子；子宫动脉；妊娠；新生儿

    Pregnancy outcome affected with alterations of uterine artery hemodynamics and serum PLGF

    TANG Yan.The Third People’s Hospital of Weiyuan，Weiyuan 642469，China

    [Abstract] Objective To determine the effects of alterations in uterine artery hemodynamics and serum PLGF on the pregnancy outcome.Methods Clinical data of 162 pregnant women were analyzed during 2005/3～2006/4.at 10～14 weeks’ gestation，their peripheral blood samples were harvested to measure the PLGF levels with ELISA.Since 20～24 weeks’ gestation，the S/D ratio，RI，PI in both sides of uterine artery was monitored with color Doppler ultrasound.All the cases of women and newborn were followed up till 3 months postpartum.Results The mean of serum PLGF in hypertensive patients (36.2±8.3)pg/ml was significantly lower than that in normal ones (52.9±9.6)pg/ml (P<0.01).The S/D ratio ......