纳米羟基磷灰石复合rhBMP-2修复骨纤维结构不良骨缺损
纳米羟基磷灰石；骨形态发生蛋白；骨纤维结构不良,,],纳米羟基磷灰石；骨形态发生蛋白；骨纤维结构不良,1资料与方法,3讨论,[参考文献]
[摘要] 目的 探讨纳米羟基磷灰石复合rhBMP-2修复骨缺损的成骨能力。方法 选取9例骨纤维结构不良病例，手术刮除病变组织造成骨缺损，用纳米羟基磷灰石复合rhBMP-2完全填充骨缺损，术后随访分别做肝肾功能、免疫学指标检测和X线片检查，以了解材料对人体有无毒性、免疫反应和骨修复情况。结果 术后肝肾功能、免疫学指标检测均在正常范围，X线片见植入材料术后24个月基本被骨组织爬行替代。结论 纳米羟基磷灰石复合rhBMP-2是一种理想的骨缺损修复材料。[关键词] 纳米羟基磷灰石；骨形态发生蛋白；骨纤维结构不良
Nano-.hydroxyapatite compounding rhBMP-2 in reconstruction of osteofibrous dysplasia and bone defect
YU Zhi-.qing,QU Xiang-.yang.Linshui Peoples Hospital,Sichuan 638500,China
[Abstract] Objective Approaching the bone formation ability of repairing bone defect by nano-.hydroxyapatite compounding rhBMP-2.Methods There were 9 cases of osteofibrous dysplasia.We erasioned proc tissue resulting in bone defect through operation,and filled the bone defect by nano-.hydroxyapatite compounding rhBMP-2 completely.We detected liver and kidney function,X-.ray examination to understand information of toxicity,immune reaction and bone reparation by post-.operation follow-.up.Results The results of liver and kidney function were in normal range.The transplanted materials were substituted for bone tissue by creeping through X-.ray examination after 24 months.Conclusion The material of nano-.hydroxyapatite compounding rhBMP-2 is an ideal material of repairing bone defect. ......
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