DENG Jieª²Xi1, ZHANG Junª²Song1, QIU Yueª²Ling2, DOU Yan1, CHEN Jinª²Song1, SUN Tingª²Ting1, GUO Shouª²Gui1, LIN Gengª²Hai1

    1Cardiovascular and Geriatric Department, 2Tuberculosis Center of Nanjing Military Area Command, PLA 175 Hospital, Zhangzhou 363000, China

    ¡¾Abstract¡¿ AIM: To observe the effects of amiodarone on persistent sinus tachycardia during an acute exacerbation of chronic obstructive pulmonary disease(COPD). METHODS: The COPD patients in an acute exacerbation were divided into 3 groups according to their heart rate (HR) after 2 h basic treatment, including proper oxygen administration, antiª²infection therapy, acidª²base and electrolyte rebalance, eliminating phlegm, spasmolysis and antiasthma. Group A (n=112) was intravenously administrated with 150 mg amiodarone, and their HR was above 120 beats/min(BPM) after basic treatment. Group B included 79 patients with heart rate above 120 BPM after basic treatment and wasn¬ðt administrated with amiodarone. Group C included 121 patients, whose HR was below 120 BPM after basic treatment. The parameters of HR,breath rate (BR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and the main parameters of their bloodª²gas analysis of artery blood were observed at 2 and 3 h after basic treatment in group B and C, and at the moments before and after amiodarone injection in group A. RESULTS: HR and BR of patients in group A were decreased significantly (142.6¡À18.3 vs 97.4¡À17.4, 35.2¡À7.6 vs 23.8¡À5.4, P<0.05)after amiodarone injection. Blood pressure didn¬ðt change. The parameters of bloodª²gas analysis of their artery blood after injection were significantly better than those befor injection in group A (P<0.05), even better than those in group B and group C (P<0.05). CONCLUSION: The intravenous injection of amiodarone can be used efficiently and safely in patients with persistent sinus tachycardia during an acute exacerbation of COPD. ......