HUO Xiaoª²Ping1, GU Xueª²Lan1, LIU Liangª²Ming2, DIAO Youª²Fang2, MA Chunª²Yan1, CHEN Jiaª²Hui1, LI Ping2, LU Shiª²Yue1, LIU Jianª²Cang2, XU Qiang3

    1Jiangsu Simcere Pharmaceutical Research Company LTD, Nanjing 210042, China, 2Second Department of Research, Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China, 3Academy of Life Sciences, Nanjing University, Nanjing 210093, China

    ¡¾Abstract¡¿ AIM: To investigate the effect of edaravone(ED), a novel free radical scavenger, on cardiac function and myocardial cell injury in rats with septic shock. METHODS: After treatment with three different doses (6.0, 3.0 and 1.5 mg/kg) of ED to rats 1 h after septic shock, changes of MAP, LVESP, LVEDP,¡Àdp/dtmax were determined in 4 different time phases. The activities of SOD, CAT, LDH and the concentrations of MDA, LD in myocardial tissue were measured. The pathologic change of myocardial tissue was observed by HE staining. RESULTS: Compared with septic shock group, MAP,LVESP and +dp/dtmax were increased remarkably in ED treatment groups. The activities of SOD and CAT and the concentration of MDA in ED groups were close to those in normal control group. Histological examination showed congestion, edema and inflammatory cell infiltration in myocardial tissue, while ED treatment attenuated the above pathological changes of myocardium. CONCLUSION: ED has a satisfying therapeutic effect on cardiac dysfunction in rats with septic shock, which may be related to attenuating myocardial injury. ......