LIANG Rongª²Gan1, LIU Weiª²Bing2, TANG Zuª²Nian1, XU Qing1

    1Department of Pharmacology, Guilin Medical College, 2College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin 541004, China

    ¡¾Abstract¡¿ AIM: To evaluate the antiª²respiratory syncytial virus (RSV) effect of flavonoids extracted from the core of Litchi Chinensis in cell culture in vitro. METHODS: By the method of cell culture and using ribavirin as a positive control, the cytopathic effect(CPE) was observed. RESULTS: The TC50 and IC50 of the flavonoids extracted from the core of Litchi Chinensis was 152.9 mg/L and 58.6 mg/L respectively. The therapeutic index (TI) was 2.6, It had the same effect as Ribavirin in antiª²RSV. Moreover, flavonoids extracted from the core of Litchi Chinensis also showed a concentrationª²dependent response in inhibiting RSV. CONCLUSION: Flavonoids extracted from the core of Litchi Chinensis can inhibit RSV in Hepª²2 cells in vitro. ......