LI Shengª²Lian1, ZHOU Yingª²Qiong2, OU Chaoª²Yan1, LI Chengª²Gong2, YE Zuª²Yang3, HUANG Xiang3, LU Riª²Mei3

    1Department of Preventive Medicine, 2Department of Pathological Anatomg, 3Department of Clinical Care Guilin Medical College, Guilin 541004, China

    ¡¾Abstract¡¿ AIM: To study the possible hepatotoxicity of Wistar rats induced by sodium dodecyl sulfate(SDS). METHODS: SDS was added into the drinking water for getting the final concentrations as 1000, 100, 10 and 0 g/L respectively. Then let the rats drink the contaminated water freely for 7 weeks. After the experiment, the rats were killed and ALT, AST, LDH, ALP and ¦Ãª²GT in the serum were assayed, and then the hepatic cells of the rats were examined in the way of pathomorphology. RESULTS: The activities of AST, LDH, ALT and ¦Ãª²GT in 100 g/L group increased (P<0.05 vs the control group), and then decreased in 1000 g/L group (P<0.01 vs 100 g/L group); the activity of ALP in the experimental groups made no statistical significance compared with that of the control group.The pathological examination showed that the pathologic change of the liver tissues in the 10 g/L group made no difference from that in the control group, and the hepatic cells suffered from mild edema, fatty degeneration in the 100 g/L group; while the hepatic cells suffered from moderate edema and fatty degeneration and sporadic necrosis lesions in the 1000 g/L group. CONCLUSION: Longª²time drinking the water containing SDS will do harm to the liver and cause reverse change of enzymes in the serum. ......