胰岛素抵抗与原发性高血压的关系研究(pdf)

    【摘要】 目的 探讨胰岛素抵抗与原发性高血压的关系。方法 2000例健康查体者在排除了高血压史、冠心病、脑血管病、糖尿病、前列腺肥大、肝炎、慢性支气管炎、胃肠炎等疾病及既往史后选取42例，根据其血压状态分为正常血压组(A组，收缩压<120 mmHg，舒张压<80mmHg)14例，正常高值组(B组，120mmHg≤收缩压<140mmHg或80mmHg≤舒张压<90mmHg)14例，高血压组(C组，收缩压≥140mmHg或舒张压≥90mmHg)14例，测定其空腹血糖(FBG)、空腹血清胰岛素(FINS)。结果 与A组比较，B组胰岛素抵抗指数差异无显著性，C组则显著增高(df＝7.72，t＝1.860，P=0.043<0.05)；与B组相比，C组差异无显著性。结论 原发性高血压病人存在明显的胰岛素抵抗状态。

    【关键词】 胰岛素抵抗； 原发性高血压

    The relationship between insulin resistance and primary hypertension

    MA Ya-bing, GAO Hai-qing, LI Bao-ying,et al. Qilu Hospital of Shandong University, Jinan 250012, China

    【Abstract】 Objective To study the relationship between insulin resistance and primary hypertension. Methods 42 people were selected from 2000 people who have taken healthy examination, with hypertension history、coronary artery disease,brain angiopathy,prostatomegaly、hepatitis、chronic bronchitis、diabetes and gastroenteritis, etc. and their history excluded. The subjects were divided into three groups according to their value of blood pressure. There were 14 people in the normal control group (group A, systolic pressure<120 mmHg and diastolic pressure<80 mmHg), 14 people in the prehypertension group (group B, 120 mmHg≤diastolic pressure<140 mmHg or 80 mmHg≤diastolic pressure<90 mmHg), 14 people in the hypertension group (C group, systolic pressure≥140 mmHg or diastolic pressure≥90 mmHg). Their fasting blood glucose (FBG) and fasting insulin (FINS) were determined. Results Compared with the group A, the insulin resistance index (IRI) did not show statistics difference in the group B, but it was remarkably advanced in the group C. Compared with the group B, the IRI did not show statistics difference in the group C. Conclusion There are remarkable insulin Resistance in primary hypertension patients. ......