对抗抑郁剂维持性治疗过程中抑郁症病人复发或复燃的分析
抗抑郁剂维持性治疗,复发或复燃,相关因素,,抗抑郁剂维持性治疗,复发或复燃,相关因素,1对象和方法,2结果,3讨论,参考文献
【摘要】目的 探讨抗抑郁剂维持性治疗过程中抑郁症病人复发或复燃的因素。方法 将140例坚持服用抗抑郁剂治疗者分为A、B两组(A组42例，为一年内复发或复燃者；B组98例，为一年内未复发或复燃者)，对两组进行一般情况，伴精神病性症状，伴躯体化症状、伴焦虑症状、双重抑郁等对照。结果 两组在年龄、家族史、婚姻质量、慢性心因、伴精神病性症状、躯体化症状、双重抑郁和焦虑症状等方面比较均有显著差异。且发现45~55岁年龄段妇女复发率最高。使用SNRI、三环类及四环类药物维持性治疗者，其复发率低于使用SSRI类药物者。更多的应激存在于A组中。入组时HAMD的分值与复发无相关性，但缓解时HAMD的分值与复发有相关性。结论 预防抑郁症的复发，既要重视药物维持性治疗，又要改善其他方面的影响因素。【关键词】 抗抑郁剂维持性治疗 复发或复燃 相关因素
Analysis of recurrence and relapse in treating major depression by antidepressants maintenance therapy.LI Yiyun,JIA Chunhong,XU Jing,et at.The Fourth People's Hospital of Zhenjiang,Jiangsu 212001,China
【Abstract】Objective To explore the factors of relapse and recurrence in treating major depression by antidepressants maintenance therapy.Method 140 patients taking antidepressants were divided into group A and group B(42 cases in group A,who had relapse or recurrence in one year,98 cases in group B,without recurrence during one year),those whose general condition,psychotic symptoms ,somatic symptome,anxiety and double depression were compared with between the two groups.Results There were significant difference in those aspects of age,family history,marital quality,chronic psychogenic factors,psychotic symptoms,somatic symptoms,double depression and anxiety between group A and group B.The highest rate of recurrence occurred in female aged from 45 to 55 yearold.The recurrence rate of the patients in maintenance therapy with SNRI,tricyclics and tetracyclics was lower than those with SSRI.It existed more stress in group A.HAMD scores had no relevance to recurrence at enrolment,but HAMD scores had relevance to recurrence in recovery.Conclusion In order to preventing major depression from recurrence,we should pay attention to the drug maintenance therapy and improve some effect factors as well. ......
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