表遗传学与胃肠道肿瘤
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朱新江, 戴冬秋
胃肠道肿瘤;基因调控;DNA甲基化;组蛋白修饰,朱新江,戴冬秋,戴冬秋,通讯作者:,电话:,收稿日期:,接受日期:,Epigeneticmodificationan
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朱新江, 戴冬秋, 中国医科大学附属第一医院肿瘤外科 辽宁省沈阳市 110001
国家自然科学基金资助项目, No. 30572162, No. 30271477
教育部高校博士点基金资助项目, No. 20050159001
戴冬秋, 中国医科大学医学博士, 教授, 主任医师, 博士生导师. 2000-2002年美国M.D.安德森癌症中心博士后研究员, 中国抗癌协会全国胃癌专业委员会委员, 《CMJ》及《世界华人消化杂志》等5刊编委及审稿人. 主要从事肿瘤外科, 化疗及生物治疗等工作, 专于胃癌转移分子机制及早期预测与阻断的基础和临床研究.
通讯作者: 戴冬秋, 110001, 沈阳市和平区南京北街155号, 中国医科大学附属第一医院肿瘤科, 辽宁省胃癌分子病理重点实验室. daidq63@163.com
电话: 024-83283560
收稿日期: 2006-09-28 接受日期: 2006-10-11
Epigenetic modification and gastrointestinal tumor
Xin-Jiang Zhu, Dong-Qiu Dai
Xin-Jiang Zhu, Dong-Qiu Dai, Department of Oncology Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Supported by National Natural Science Foundation of China, No. 30572162, No. 30271477, and the Scientific Research Foundation of Education Ministry for the Doctors, No. 20050159001
Correspondence to: Dr. Dong-Qiu Dai, Department of Oncology Surgery, the First Affiliated Hospital of China Medical University,155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province,China. daidq63@163.com
Received: 2006-09-28 Accepted: 2006-10-11
AbstractCarcinogenesis springs from the combined forces of both genetic and epigenetic events. The role of epigenetic modification in the progression of carcinoma has been suggested by a lot of evidences in recent years. An epigenetic event alters the activity of genes without changing their structure. Gastrointestinal tumor is the most common cancer in China, and the investigation of epigenetic modification is significant in cell immunity, phylaxis, cell differentiation and preventive therapy.
Key Words: Gastrointestinal tumor; Gene regulation; DNA methylation; Histone modification
Zhu XJ, Dai DQ. Epigenetic modification and gastrointestinal tumor. Shijie Huaren Xiaohua Zazhi 2006;14(34):3251-3256 ......
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