肝硬化患者外周血单核细胞表面TLR4和TLR2表达的临床意义
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苟艳子, 连建奇, 聂青和, 庄 严, 刘清泉,
Toll样受体;肝硬化;抗生素;流式细胞术;单克隆抗体,苟艳子,连建奇,聂青和,庄严,刘清泉,邵彬,苟艳子,通讯作者:,电话:
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苟艳子, 连建奇, 聂青和, 庄严, 刘清泉, 邵彬, 第四军医大学唐都医院传染病科、全军感染病诊疗中心 陕西省西安市 710038
苟艳子, 第四军医大学硕士, 主治医师, 主要从事传染病学基础与临床研究. 中华肝炎防治基金会基金, No. 2006ALBPA1
通讯作者: 连建奇, 陕西省西安市, 第四军医大学唐都医院传染病科、全军感染病诊疗中心. lianjq@fmmu.edu.cn
电话: 029-84777853 传真: 029-83537377
收稿日期: 2006-07-28 接受日期: 2006-08-22
Clinical significance of Toll-like receptor 4 and 2 expression on the surface of peripheral blood mononuclear cells in patients with liver cirrhosis
Yan-Zi Gou, Jian-Qi Lian, Qing-He Nie, Yan Zhuang, Qing-Quan Liu, Bin Shao
Yan-Zi Gou, Jian-Qi Lian, Qing-He Nie, Yan Zhuang, Qing-Quan Liu, Bin Shao, Center of Diagnosis and Treatment for Infectious Diseases of Chinese PLA, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China
Supported by the Fund for Hepatitis Prevention and Treatment of China, No. 2006ALBPA1
Correspondence to: Dr. Jian-Qi Lian, Center of Diagnosis and Treatment for Infectious Diseases of Chinese PLA, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, Shaanxi Province,China. lianjq@fmmu.edu.cn
Received: 2006-07-28 Accepted: 2006-08-22
Abstract
AIM: To explore the correlation of Toll-like receptor 4, Toll-like receptors 2 expression on the surface of peripheral blood mononuclear cells with bacterial infection in patients with liver cirrhosis, and observe the effect of antibiotics on PBMC expression of TLR4 and TLR2 in cirrhosis.
METHODS: Blood cells from a total of 42 patients (30 with ascites, 12 without ascites) with liver cirrhosis and 15 normal controls were stained with fluorescent labeling anti-TLR2/anti-TLR4/anti-CD14 monoclonal antibodies. Samples were collected and analyzed for three-color immunofluorescence by flow cytometry.
RESULTS: The expression of TLR4 and TLR2 were significantly higher in patients with ascites than those in the controls (TLR4: 22 ......
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