老年脑卒中患者血浆ACE水平及其基因多态性的研究
脑血管意外；,肽基二肽酶A；,老年人,1对象与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨老年脑卒中患者血管紧张素转换酶(ACE)基因插入/缺失多态性与其血浆ACE水平的关系。 方法 应用多聚酶链反应(PCR)方法检测ACE基因多态性，同时用比色法测定血清ACE水平。对50例老年脑卒中患者与50例老年健康对照者进行比较分析。 结果 老年脑卒中组D等位基因频率显著高于对照组(P<005), DD基因型患者血清ACE水平亦显著高于对照组(P<005)。 结论 血浆ACE水平和ACE基因多态性有关，提示D等位基因可能与老年脑卒中的危险因素有关。【主题词】 脑血管意外； 肽基二肽酶A； 老年人
Study of ACE gene polymorphism and serum ACE level in elderly patients with cerebral stroke ZENG Aiping .Department of Geriatrics，the 454th Hospital of PLA ，Nanjing 210002 China； MA Jianfang .Department of Geriatrics of Fuzhou General Hospital of Nanjing Military Region，Fuzhou 350002 China
【Abstract】 Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and serum ACE level in elderly patients with cerebral stroke. Methods Polymerase chain reaction(PCR) was used to examine ACE gene polymorphism. The distribution of three ACE genotypes frequencies and D allele frequency in 50 elderly patients with cerebral strokes were compared with those in 50 healthy controls, whose serum ACE levels were measured with colorimetric technique. Resukts The frequency of D allele was higher in the stroke group than that in healthy controls (P<005).A significant difference in serum ACE level of DD genotype was observed between the stroke group and control group (P<005). Conckusions Serum ACE level was associated with ACE gene I/D polymorphism. It suggests that D allele might be a genetic risk factor for stroke in the elderly. ......
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