脑血灵颗粒剂；脑出血；炎症；肿瘤坏死因子α；白细胞介素1；

脑血灵颗粒对脑出血大鼠炎症相关基因表达的影响

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脑血灵颗粒剂；脑出血；炎症；肿瘤坏死因子α；白细胞介素1；一氧化氮合酶,,脑血灵颗粒剂；脑出血；炎症；肿瘤坏死因子α；白细胞介素1；一氧化氮合酶,脑血灵颗粒对脑出血大鼠炎症相关基因表达的影响

     Effect of Naoxueling granule on expressions of inflammationrelated genes after intracerebral hemorrhage in rats

    ZHENG An, YE QinYong, LIN QiuCheng, HUANG HuaPin, LIU Nan

    Department of Neurology, Affiliated Union Hospital, Fujian Medical University, Fujian Provincial Institute of Traditional Chinese Medicine, Fuzhou 350001,China

    【Abstract】 AIM: To investigate whether Naoxueling granule can inhibit the inflammatory cascade reaction after intracerebral hemorrhage in rats. METHODS: Male SD rats received an infusion of 50 μL autologous blood into the right basal ganglia. The rats were randomly divided into sham operated group, model group, Huatuozaizao bolus group and Naoxueling granule group. The expressions of TNFα, IL1β, iNOS were observed by immunohistochemistry and in situ hybridization. RESULTS: The expressions of TNFα, IL1β, iNOS all increased on 7 d after modeling . Naoxueling granule markedly decreased the expressions of TNFα, IL1β, iNOS at the protein and mRNA levels. Compared with the model group, Huatuozaizao bolus group had no significant difference in the expressions of TNFα, IL1β and iNOS. CONCLUSION: The mechanism of Naoxueling granule against intracerebral hemorrhage may be related to the effect of inhibiting inflammatory cascade reaction. ......

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