甲状腺;_良、恶性病变；

甲状腺癌组织中galectin3、CK19的表达及应用价值

http://www.100md.com 《新疆医科大学学报》 2006年第11期

甲状腺;,良、恶性病变；,细胞角蛋白19；,半乳糖凝集素3；,免疫组织化学,,甲状腺;,良、恶性病变；,细胞角蛋白19；,半乳糖凝集素3；,免疫组织化学,甲状腺癌组织中galectin3、

     摘要：目的：探讨半乳糖凝集素3(galectin3)和细胞角蛋白19(CK19)在甲状腺良、恶性病变组织中的表达及应用价值。方法：采用免疫组织化学方法(SP法)检测68例甲状腺良、恶性病变组织中galectin3 、CK19的表达情况，比较有、无淋巴结转移甲状腺癌组织中galectin3、CK19的表达差异，并计算检测的灵敏度和特异度。结果：30例甲状腺癌组织中galectin3、CK19阳性表达率分别为90.0%、96.7%,38例甲状腺良性病变组织中阳性表达率分别为15.8%、7.9%,良、恶性病变组织阳性表达率差异有统计学意义(P<0.05)。淋巴结转移甲状腺癌组织中galectin3的阳性表达率为100.0%，无淋巴结转移甲状腺癌组织的阳性表达率为62.5%，差异有统计学意义(P<0.05)。淋巴结转移甲状腺癌组织CK19的阳性表达率为100.0%，无淋巴结转移甲状腺癌组织的阳性表达率为87.5%，差异无统计学意义(P>0.05)。galectin3联合CK19检测甲状腺良、恶性病变的灵敏度、特异度分别为90.0%、92.1% ,单独检测galectin3的灵敏度、特异度分别为90.0%、84.2%、96.7%、92.1%。结论： galectin3的表达与颈淋巴结转移有关,对预测甲状腺癌的发展及淋巴结转移有参考价值。galectin3和CK19在甲状腺良、恶性病变组织中的表达基本平行,二者联合检测有助于鉴别甲状腺良、恶性病变。

    关键词：甲状腺; 良、恶性病变；细胞角蛋白19；半乳糖凝集素3；免疫组织化学

    Studing the value of galectin3， CK19 expression in the thyroid cancer

    XIAO Hong, DUAN Shaobin, ZHANG Jianyong, et al

    (Department of General Surgery, Affiliated Traditional Chinese Medicine Hospital,Xinjiang Medical University, Urumqi 830000, China)

    Abstract: Objective: To measure expression of galectin3, CK19 in specimens taken from the benign or malignant disease of thyroid gland. To study the value of combination detection with galectin3, CK19 in distinguishing the benign or malignant disease of thyroid gland. Methods: Immunohistochemistry (SP method) was employed in this study to detect the expression of galectin3, CK19 in the benign or malignant disease of thyroid gland. Results: (1) Expression of galectin3 was positive in 27 of 30 cases of thyroid carcinoma, the rate was 90.0%, the positive rate of benign disease was 15.8%, Compare between the benign or malignant disease of thyroid gland pathologically, the difference was high significance (P<0.05). CK19 expressed positive in 29 cases of thyroid adenocarcinoma, the positive rate was 96.7%, the positive rate in the benign disease of thyroid gland was 7.9%, the difference had high significance (P<0.05) in two groups compared. The expression of galectin3 had significance (P<0.05) with metastasis of lymph node of neck. The sensitivity, specificity were 90.0%, 92.1% respectively in distinguishing between the benign and malignant disease of thyroid gland employed in combination detection with galectin3 and CK19. While measuring galectin3 alone, the sensitivity, specificity were 90.0%, 84.2% respectively. Conclusions: The expression of galectin3 has close correlation with metastasis of lymph node of neck. Combination detection with galectin3 and CK19 can distinguish the benign or malignant disease of thyroid gland effectively. ......

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