Chemotherapy of NA and NP regimens in 48 patients with advanced breast cancer

    GUO Yaª²Huan, NAN Keª²Jun, LI Chunª²Li, ZHANG Wei

    Department of Medical Oncology, First Affiliated Hospital, Medical College, Xi¬ðan Jiaotong University, Xi¬ðan 710061, China

    ¡¾Abstract¡¿ AIM: To observe the effect and toxicity of NA and NP regimens for advanced breast cancer. METHODS: All cases of advanced breast cancer were treated with NA regimen(NVB+Eª²ADM, n=26)or NP regimen(NVB+DDP, n=22). The former refered to vinorelbine (NVB, 25 mg/m2 on day 1, 8) plus epirubicin (Eª²ADM, 60 mg/m2 on day 1) and the latter to vinorelbine (NVB, 25 mg/m2 on day 1, 8) plus cisplatin (DDP, 40 mg on day 1, 2, 3); both were performed every 3 to 4 weeks. RESULTS: NA regimen led to 61.5% response rate(RR), median survival time of 25.8 months, and 1ª²year survival rate of 61.5%. For 22 patients treated with NP regimen, the RR was 45.5%, the median survival time was 19.8 months, and the 1ª²year survival rate was 68.2%. There was no statistically significant difference between the 2 groups in the RR of the initial treatment and the median survival time and the 1ª²year survival rate (P>0.05), However, The median time to progression(mTTP) in NA regimen was longer than that in NP regimen (8.5 vs 5.0 months, ¦Ö2£½4.2, P£½0.04). The main side effects were myelosuppression and gastrointestinal tract reaction, which were all reversible. CONCLUSION£º NA regimen and NP regimen are effective and less toxic to patients with advanced breast cancer who suffered from relapse or distant metastasis. Both of the 2 regimens can be applied as the firstª²line chemotherapy for advanced breast cancer. ......