Application of sufentanil to prevent acute postoperative pain in remifentanilª²based anaesthesia

    YANG Jing, WANG Wei, ZHANG Hong, MI Weiª²Dong

    Department of Anesthesiology, Department of Orthopedics, Department of Anesthesiology, PLA General Hospital, Beijing 100853, China

    ¡¾Abstract¡¿ AIM: To investigate the postoperative analgesic effect of sufentanil used in remifentanilª²based anaesthesia with isoflurane and propofol. METHODS: Ninety patients undergoing major abdominal surgery, thoracic surgery or spine surgery respectively (n=30 in each group) were randomly assigned to sufentanil group and fentanil+ lomoxicam group, which received intravenous instillation of sufentanil (0.5 ¦Ìg/kg) and fentanil (1 ¦Ìg/kg) +lomoxicam(8 mg) respectively 25 min before the end of the operation. Isoflurane was switched off 10 min before the end of surgery. And after skin closure, remifentanil and propofol were switched off. Time to resumption of spontaneous respiration, eye opening and extubation were recorded, and pain was evaluated and the number of the patients who needed the second dose of fentanil was recorded. RESULTS: There were no significant differences in the time to resumption of spontaneous respiration, eye opening and extubation between sufentanil group and fentanil+lomoxicam group. The patients having moderate to severe pain in sufentanil group was fewer than fentanil+ lomoxicam group (P<0.01). In sufentanil group fewer patients required a second dose of opioid (P<0.01), while more than 30% required a second dose of opioid after extubation in fentanil+ lomoxicam group. CONCLUSION: Intraoperative administration of sufentanil (0.5 ¦Ìg/kg) 25 min before the end of the operation can provide immediate pain relief postoperativity without severe effects on recovery time in remifentanilª²based anaesthesia. ......