[摘要] 目的 探讨核素99mTc-MDP骨显像在骨质疏松症诊断中的应用价值。方法 37例患者先行双能X线骨密度测定，然后行核素99mTc-MDP全身骨显像，利用感兴趣区法分别获取全身、颅骨、胸骨、腰椎、股骨放射性计数，计算各部位与全身放射性计数比值，并与双能X线行相关性分析。结果 核素99mTc-MDP骨显像测定骨质疏松组颅骨、胸骨、腰椎、股骨之间放射性计数比值分别为0.09±0.020、0.02±0.005、0.04±0.005、0.06±0.003，正常组分别为0.05±0.013、0.01±0.004、0.02±0.004、0.05±0.006，两组之间差异具有非常显著性(t值分别为8.51、6.89、13.78、6.15，P均<0.01)，正常组及骨质疏松组腰椎、股骨放射性计数比值与双能X线之间均具有明显相关性(r=0.9、0.71、0.82、0.83，P<0.05)。结论 核素99mTc-MDP骨显像测定法在骨质疏松诊断应用中与双能X线具有较好的相关性，且具有高灵敏性，对骨质疏松症的诊断具有较高价值。

    [关键词] 99m锝；放射性核素；核素骨显像；骨密度；骨质疏松症；诊断

    Comparison on value of radionuclide bone imaging with osteodensitometry in diagnosis of osteoporosis

    LIU Bing-ji,ZUO Shu-yao.Department of Nuclear Medicine,the Affiliated Hospital of Medical College,Qingdao University,Qingdao 266003,China

    [Abstract] Objective To investigate the clinical significance of radionuclide bone imaging in diagnosis of osteoporosis.Methods The bone mineral density (BMD) was detected by dual energy X-ray absorptiometry(DXA) in 37 cases.The radionuclide whole body bone imaging was performed to the same 37 cases to get the counts of the whole body,skull,sternum,lumbar vertebrae and the femur seperately by drawing region of interest(ROI).Then the counts of each site to the whole body were caculated.Correlation analysis was used to the BMD and the radiocounting ratios.Results The radiocounting ratios of skull,sternum,lumbar vertebrae and the femur in osteoporosis group were respectively 0.09±0.020,0.02±0.005,0.04±0.005,0.06±0.003,and the normals were 0.05±0.013,0.01±0.004,0.02±0.004,0.05±0.006.Significant difference was found beween groups and within groups (t values were 8.51,6.89,13.78,6.15 ......