Effect of rotatory stimulation on plasma level of calcitonin geneª²related peptide in rats

    WANG Xiaoª²Cheng, FENG Liª²Ning, ZHANG Zuoª²Ming

    Department of Clinical Medicine, School of Aerospace Medicine, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To explore the relation between calcitonin geneª²related peptide (CGRP) and motion sickness(MS) in rats. METHODS: A group of 30 rats were subdivided into 4 experimental groups and a control group with a random number table. The rats of experimental groups were treated with rotatory stimulation for 30 min. Then the plasma levels of CGRP in 4 experimental groups were measured respectively 20 min, 6 h, 1 and 3 d after the stimulation.According to the changes of rat¬ðs intake of saccharin solution before and 24 h after rotatory stimulation for 15 min. Another group of 20 rats were subdivided into a group sensitive to MS and a group insensitive to MS, then the plasma levels of CGRP in the 20 rats were measured 20 min after rotatory stimulation for 15 min. RESULTS: There was no significant difference in the plasma levels of CGRP at different time points after rotatory stimulation in the first group (F=1.105, P=0.893); there was no significant difference in the plasma levels of CGRP between the group sensitive to MS and the group insensitive to MS (P=0.704). CONCLUSION: The CGRP in blood plasma doesn¬ðt play an role in the pathogenesis of MS. ......