急性脑梗死_动脉内溶栓_尿激酶____

急性脑梗死动脉内溶栓治疗研究

http://www.100md.com 《临床心身疾病杂志》 2006年第4期

急性脑梗死,动脉内溶栓,尿激酶,,急性脑梗死,动脉内溶栓,尿激酶,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的观察超选择脑动脉内溶栓治疗急性脑梗塞的疗效。方法 164例急性脑梗死患者采用超选择脑动脉内溶栓方法，起病距溶栓时间3~6h，尿激酶以1.0万μ·min-1持续泵入，总量为100万μ，辅助其它常规治疗，治疗14d后评价其临床疗效。结果溶栓有效率为90.2%，显效率为60.4%，血管再通率为72.9%，治疗后神经功能缺损评分较前显著降低(P<0.01)。结论超选择脑动脉内溶栓可使血栓局部迅速达到较高的血药浓度，是治疗急性脑梗死的有效方法。

    【关键词】急性脑梗死动脉内溶栓尿激酶

    Clinical evaluation of intraarterial thrombolysis in acute cerebral infarction

    Zhang Mingqiu，Yang Ruimin，Zhao Hongzeng, et al

    (Imaging and Interventional Centre, The First Affiliated Hospital, Xinxiang Medical College, Weihui 453100, China)

    【Abstract】 Objective To observe the effect of infraarterial thrombolysis on the actute cerebral infarction. Methods 164 patients with acute cerebral infarction were treated by superselective infra-arterial thrombolysis in 3~6 hours after onset of the symptoms of cerebral infarction. Urokinase (UK) was infused into the infracted cerebral artery at the rate of 10 000 unit/min. The total dosage of UK was 1 000 000 units. The patients were given routine treatment. The curative effect were evaluated 14 days after the treatment. Results The rate of effective, excellence, recanalization were 90.2% and 60.4% and 72.9% respectively.The neurological deficit scale score was significantly lower than before (P<0.01). Conclusion The superselective intraarterial thrambolysis is avaluable therapeutic method in the patients with acute cerebral infarction because the high UK concentration in the infarcted cerebral vassel can be reached by this method. ......

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