氧张力与软骨组织工程
氧张力;软骨;组织工程,,氧张力;软骨;组织工程,1软骨组织氧张力,2氧张力与软骨细胞增殖组织工程方法,3氧张力与软骨细胞表型分化,4氧张力与软骨细胞基质,5氧张力与间充质
摘要: 氧是细胞成活和调节细胞代谢的重要因素。软骨组织一直被认为是一种缺氧组织,正常关节软骨没有血管供应,其氧供只能依靠周围滑液的渗透作用。目前软骨组织工程种子细胞基本采用标准氧培养环境,氧张力为20%~21%,距体内正常软骨细胞和间充质干细胞氧张力环境有很大差距。本文综述了近年来有关氧张力对软骨细胞和间充质干细胞生物学作用的研究进展。关键词:氧张力;软骨;组织工程
Oxygen tension and cartilage tissue engineering
CHEN Shujun,JI Ning,PEI Guoxian
(Center of Tissue engineering Research,Southern Medical University,Department of Orthopedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)
Abstract: Cartilage has often been thought of as an anaerobic tissue. However,oxygen levels in standard culture conditions is 20%21%,which is hyperphysiologic for cartilage tissue engineering cell types,including chondrocytes and bonemarrow derived MSCs.As a regulating agent of chondrogenesis,oxygen has gained increasing attention.This article reviewed the development of oxygen levels in cartilage tissue engineering.
Key words:oxygen tension;cartilage;tissue engineering
关节软骨愈合能力有限,软骨组织工程研究的发展为关节软骨缺损的治疗提供了新的治疗手段,使软骨组织缺损的完全再生成为可能。考虑到潜在的免疫排斥反应和疾病交叉感染,目前的种子细胞研究倾向于自体细胞来源。自体细胞的研究内容涉及细胞的获取、扩增和表型稳定性保持以及细胞移植后的功能表达 ......
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