CD14与酒精性肝病
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吴 涛, 季 光, 郑培永
白细胞分化抗原14;酒精性肝病;脂多糖;信号传导,吴涛,季光,郑培永,季光,通讯作者:,RoleofCD14inalcoholicliverdisease,TaoWu
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吴涛, 季光, 郑培永, 上海中医药大学附属龙华医院肝病研究室 上海市 200032
季光, 主任医师, 博士生导师, 上海中医药大学附属龙华医院消化内科教授, 主要从事中医药防治慢性肝病的研究.
国家自然科学基金资助课题, No. 30572380
通讯作者: 季光, 200032, 上海市, 上海中医药大学附属龙华医院肝病研究室. jiliver@vip.sina.com
电话: 021-64286261 传真: 021-64286261
收稿日期: 2006-09-29 接受日期: 2006-10-16
Role of CD14 in alcoholic liver disease
Tao Wu, Guang Ji, Pei-Yong Zheng
Tao Wu, Guang Ji, Pei-Yong Zheng,Department of Liver Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Supported byNational Science Foundation of China, No. 30572380
Correspondence to:Guang Ji, Department of Liver Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. jiliver@vip.sina.com
Received:2006-09-29 Accepted:2006-10-16
Abstract
CD14 (cluster of differentiation antigen), the receptor of LPS (lipopolysaccharide), plays a key role in a series of responses of the body immune and recovery system. Membrane CD14 not only recognizes LPS, but also induces tyrosine’s phosphorylation, transposes NF-κB (nuclear factor-κB), triggers the release of cytokines, generates the oxygen free radicals. But the soluble CD14 competes with membrane CD14 in binding LPS, and mediates the response to LPS of the endothelial cells and smooth muscle cells which do not express membrane CD14. In recent years, it is demonstrates that CD14 plays an important role in the pathogenesis of alcoholic liver disease.
Key Words: Cluster of differentiation antigen 14; Alcoholic liver disease; Lipopolysaccharide; Signal transduction
Wu T, Ji G, Zheng PY. Role of CD14 in alcoholic liver dis-ease. Shijie Huaren Xiaohua Zazhi 2006;14(35):3341-3347
摘要
白细胞分化抗原14(cluster of differentiation antigen, CD14)为内毒素脂多糖(lipopolysac-charide, LPS)高亲和力受体, 在机体免疫、防御系统引起的一系列反应中起着关键的作用. 细胞膜CD14识别LPS并引起细胞酪氨酸磷酸化、核因子(nuclear factor-κB, NF-κB)转位、触发细胞因子释放和氧自由基的产生 ......
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