磁性纳米控释紫杉醇对食管癌Eca109细胞株生长的影响
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陈 萍, 施瑞华, 凌亭生
磁性纳米控释紫杉醇;食管肿瘤;细胞周期;细胞凋亡,陈萍,施瑞华,凌亭生,陈萍,通讯作者:,Effectsofmagneticnano-c
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陈萍, 施瑞华, 凌亭生, 南京医科大学第一附属医院消化内科 江苏省南京市 210029
陈萍, 南京医科大学在职硕士研究生, 马鞍山市中心医院消化内科主治医师, 主要从事食管癌的研究.
江苏省卫生厅资助项目, No. 2001-31
通讯作者: 施瑞华, 210029, 江苏省南京市, 南京医科大学第一附属医院消化内科. ruihuashi@126.com
电话: 025-83718836-6255
收稿日期: 2006-08-28 接受日期: 2006-09-25
Effects of magnetic nano-controlled release paclitaxel on the growth of esophageal carcinoma cell line Eca109
Ping Chen, Rui-Hua Shi, Ting-Sheng Ling
Ping Chen, Rui-Hua Shi, Ting-Sheng Ling,Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Supported bythe Fund from Sanitation Office of Jiangsu Province, No. 2001-31
Correspondence to:Rui-Hua Shi, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. ruihuashi@126.com
Received:2006-08-28 Accepted:2006-09-25
Abstract
AIM: To observe the effects of magnetic nano-controlled paclitaxel at different concentrations on the growth of esophageal carcinoma cell line Eca109.
METHODS: Eca109 cells in logarithmic growth phase were treated by magnetic nano-controlled release paclitaxel at different concentrations, fluorouracil (5-FU) and Taisu, while dimethylsurfoxide (DMSO) and RPMI 1640 were used in the control cells. MTT assay was used to examine the inhibitory rate through the absorbency of 24, 48, and 72 h. After Eca109 cells were disposed by magnetic nano-controlled release paclitaxel at different concentrations for 72 h, the cellular ultrastructure was observed under electron microscope and cell cycle and apoptosis were analyzed by flow cytometry.
RESULTS: Magnetic nano-controlled release paclitaxel inhibited the proliferation of Eca109 cell in vitro, and the effect had characteristic of slower release in comparison with that of 5-FU or Taisu (78.1% vs 60.0%, 63 ......
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