重组Canstatin蛋白联合氟尿嘧啶治疗胰腺癌
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何小平, 朱人敏, 王震凯, 汪芳裕, 张晓华,
胰腺癌;血管生成;Canstatin蛋白,何小平,朱人敏,王震凯,汪芳裕,张晓华,刘炯,王琳,何小平,通讯作者:,Efficacyofreco
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何小平, 朱人敏, 王震凯, 汪芳裕, 张晓华, 刘炯, 王琳, 南京军区南京总医院消化内科 江苏省南京市 210002
何小平, 主治医师, 医学博士, 主要从事肿瘤基因治疗的研究.
通讯作者: 朱人敏, 21002, 江苏省南京市中山东路305号, 南京军区南京总医院消化内科. zhurenmin51@126.com
电话: 025-80861126
收稿日期: 2006-07-23 接受日期: 2006-09-28
Efficacy of recombinant Canstatin protein plus fluorouracil in treatment of pancreatic cancer
Xiao-Ping He, Ren-Min Zhu, Zhen-Kai Wang, Fang-Yu Wang, Xiao-Hua Zhang, Jiong Liu, Lin Wang
Xiao-Ping He, Ren-Min Zhu, Zhen-Kai Wang, Fang-Yu Wang, Xiao-Hua Zhang, Jiong Liu, Lin Wang,Department of Gastroenterology, Nanjing General Hospital of Nanjing Military Command of Chinese PLA, Nanjing 210001, Jiangsu Province, China
Correspondence to:Ren-Min Zhu, Department of Gastroenterology, Nanjing General Hospital of Nanjing Military Command of Chinese PLA, Nanjing 210001, Jiangsu Province, China. zhurenmin51@126.com
Received:2006-07-23 Accepted:2006-09-28
Abstract
AIM: To study the anti-tumor effects of recombinant Canstatin protein plus 5-fluorouracil (5-FU) on pancreatic cancer in order to develop a new treatment modality.
METHODS: Tumor xenografts were established by subcutaneous inoculation of 1×107 SW1990 pancreatic cancer cells into the right flanks of 32 BALB/c nude mice. When the tumors reached 2-3 mm in diameter, mice were randomly divided into 4 groups: phosphate buffer solution (PBS) group were treated with PBS 0.3 mL per day for 3 weeks; Canstatin group were treated with Canstatin 5 mg/kg per day for 3 weeks; 5-FU group were treated with 5-FU 12.5 mg/kg per day for 5 days; and combination group were treated with 5-FU 12.5 mg/kg per day for 5 days plus Canstatin 5 mg/kg per day for 3 weeks. All the agents were injected intraperitoneally. During the treatment period, the subcutaneous tumors were measured by compasses and caliper every 3 or 4 days. At the end of the experiment, all the tumors were resected, and both routine pathological and immunohistochemical examinations were performed to observe the drug toxicity and intratumoral microvescular density (MVD) ......
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