慢性丙型肝炎与代谢综合征
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张锦前, 范小玲
肝癌;丙型肝炎病毒;代谢综合征;慢性丙型肝炎,张锦前,范小玲,通讯作者:,电话:,收稿日期:, 接受日期:,RelationshipbetweenchronichepatitisCandmetabolicsyndrome,Jin-QianZhang,X
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张锦前, 范小玲, 北京地坛医院 北京市 100011国家自然科学基金资助课题, No. 30600524
通讯作者: 张锦前, 100011, 北京市, 北京地坛医院. jingwanghou@yahoo.com.cn
电话: 010-64211031-2457
收稿日期: 2006-09-03 接受日期: 2006-09-25
Relationship between chronic hepatitis C and metabolic syndrome
Jin-Qian Zhang, Xiao-Ling Fan
Jin-Qian Zhang, Xiao-Ling Fan, Beijing Ditan Hospital, Beijing 100011, China
Supported by National Science Foundation of China, No. 30600524
Correspondence to: Jin-Qian Zhang, Beijing Ditan Hospital, Beijing 100011, China. jingwanghou@yahoo.com.cn
Received: 2006-09-03 Accepted: 2006-09-25
AbstractBesides liver injury and hepatocellular carcinoma (HCC), hepatitis C virus (HCV) infection is also closely related with damages of extrahepatic tissues. Studies from home and abroad confirmed that fatty degeneration had been one of the pathogenic mechanisms of chronic hepatitis C, which suggested that chronic hepatitis C was a kind of metabolic disease. HCV is closely associated with metabolic syndrome. Fatty degeneration of liver and insulin resistance may be the central link in the HCV-induced metabolic syndrome, and the molecular mechanism is the virus-induced metabolic disorder of fat in liver. Further study is need in the future.
Key Words: Hepatocellular carcinoma; Hepatitis C virus; Metabolic syndrome; Chronic hepatitis C
Zhang JQ, Fan XL. Relationship between chronic hepatitis C and metabolic syndrome. Shijie Huaren Xiaohua Zazhi 2006;14(36):3482-3486
摘要
丙型肝炎病毒感染除引起肝脏损害、肝细胞癌(hepatocellular carcinoma, HCC)有相关性之外, 还与肝外组织的损害表现密切相关. 国内外研究证实慢性丙型肝炎发病机制之一是肝脏脂肪变性, 提示是一种代谢性疾病, 丙型肝炎病毒与代谢综合征(metabolic syndrome, MS)密切相关, 肝脏脂肪变性及胰岛素抵抗可能是丙型肝炎病毒致代谢综合征的中心环节, 其分子生物机制可能是病毒致脂代谢紊乱, 但是其更加深入而确切的机制仍不完全知晓, 还有待深入研究.
关键词: 肝癌; 丙型肝炎病毒; 代谢综合征; 慢性丙型肝炎
张锦前, 范小玲. 慢性丙型肝炎与代谢综合征. 世界华人消化杂志 2006;14(36):3482-3486
0 引言
自1989年发现丙型肝炎病毒(hepatitis C virus, HCV)以来, 人们通过研究发现, HCV感染除引起肝脏损害并与肝细胞癌(hepatocellular carcinoma, HCC)有相关性外, 还与肝外组织的损害表现密切相关 ......
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