E-钙黏素、MMP2和ICAM-1的表达与胃癌中医证型的关系
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刘 龙, 许 玲, 孙大志, 魏品康
E-钙黏素;基质金属蛋白酶-2;细胞间黏附分子-1;中医证型;胃癌刘龙,许玲,孙大志,魏品康.E-钙黏素、MMP2和ICAM-1的表达与胃癌中医证型的关系. 世界华人消化杂志2006;14(36)3461-3465,刘龙,许玲
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刘龙, 许玲, 孙大志, 魏品康, 第二军医大学长征医院中医科 上海市 200003
刘龙, 第二军医大学2004级博士, 主要从事中西医结合防治消化系肿瘤的研究.国家自然科学基金资助项目, No. 30271626
通讯作者: 许玲, 200003, 上海市黄浦区凤阳路415号, 第二军医大学长征医院中医科. czzyk@smmu.edu.cn
电话: 021-63610109-73406 传真: 021-63520020
收稿日期: 2006-08-30 接受日期: 2006-10-14
Correlations of E-cadherin, matrix metalloproteinase-2 and intercellular adhesion molecule-1 expression with traditional Chinese medicine classifications of syndrome for gastric carcinoma
Long Liu, Ling Xu, Da-Zhi Sun, Pin-Kang Wei
Long Liu, Ling Xu, Da-Zhi Sun, Pin-Kang Wei, Department of Traditional Chinese Medicine, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China
Supported by National Natural Science Foundation of China, No. 30271626
Correspondence to: Dr. Ling Xu, Department of Traditional Chinese Medicine, Changzheng Hospital, the Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. czzyk@smmu.edu.cn
Received: 2006-08-30 Accepted: 2006-10-14
Abstract
AIM:To investigate the expression of E-cadherin (E-Cad), matrix metalloproteinase-2 (MMP-2) and intercellular adhesion molecule-1 (ICAM-1) in different traditional Chinese medicine (TCM) classifications of syndrome for gastric carcinoma, and explore their relationships with syndromic classifications of gastric cancer.
METHODS:A total of 59 gastric cancer cases, including the types of incoordination between liver and stomach (n = 10), insufficiency of spleen and stomach (n = 10), stomach heat due to yin deficiency (n = 9), stagnation of phlegm-damp (n = 10), retention of blood stasis toxin in the interior (n = 10) and exhaustion of both qi and blood (n = 10). The expression of E-Cad, MMP2, and ICAM-1 mRNA was determined by reverse transcription-polymerase chain reaction (RT-PCR), and the diversities were analyzed between the different syndromic types ......
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