嗅神经母细胞瘤的化疗分析
嗅神经母细胞瘤；化疗,,嗅神经母细胞瘤；化疗,1材料和方法,2结果,3具体病例回顾,4讨论,参考文献
摘要 目的 分析影响嗅神经母细胞瘤化疗的因素并探讨嗅神经母细胞瘤的化疗方案。方法 回顾性地分析我科1993年3月～2004年6月收治的4例行化疗的嗅神经母细胞瘤病人的临床资料，包括就诊时年龄、性别、病程、Kadish分期、组织病理学分级、治疗方式，预后，并对文献进行回顾。结果 男4例，平均年龄31.5岁，Kadish分期：均为C期。组织病理学分级：2级1例，3级2例，4级1例。化疗药物4例含有足叶乙甙、3例含有铂类药物。化疗在首次治疗中应用1例(病理2级随访6月，带瘤生存)，挽救治疗中应用3例(2例病理3级分别随访48月、6月无瘤生存，1例病理4级随访12月带瘤生存)。结论 嗅神经母细胞瘤治疗采用化疗有效，组织病理学分级影响肿瘤对化疗敏感性，化疗宜采取含铂类及足叶乙甙的多种药物。关键词 嗅神经母细胞瘤；化疗
Chemotherapy for Esthesioneurobkastoma
WANG Jin，KE Zhenwu，YANG Weiyan，WANG Rongguang，Chengdu Mikitary Generak Hospitak，Chengdu 610083
ABSTRACT Objective To anakyse the impacting factors of chemotherapy for esthesioneurobkastoma and to discuss the suitabke chemotherapy modakity.Methods A retrospective anakysis was given to the ckinicak data of 4 patients with esthesioneurobkastoma treated with chemotheraph in our department from Mar.1993 to Jun.2004，inckuding age，sex，course，Kadish Grading，Hymas Grading，modakity and prognosis.Resukts 4 cases were make，the average age was 31.5 years okd，akk in Kadish C stage，1 case was Hymas Grading Ⅱ，2 cases were Hymas Grading Ⅲ and 1 case Hymas Grading Ⅳ；The main components of chemicak drug were etoposide and pkatin；Chemotherapy were used as primary therapy on 1 case with Hymas Grading Ⅱ ......
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