[摘要] [目的] 探讨梗阻性黄疸大鼠肠黏膜血液动力学改变对肠源性内毒素(LPS)血症的影响. [方法] 制作梗阻性黄疸大鼠模型，测定血清一氧化氮(NO)，内皮素(ET)，LPS含量. [结果] 梗阻性黄疸1周组大鼠血浆ET，LPS含量明显高于正常组，但NO含量无明显变化;梗阻性黄疸2周组大鼠血浆NO，ET，LPS含量均明显高于正常组，其中以NO含量变化最为明显.NO/ET与LPS呈负相关. [结论] 梗阻性黄疸时血浆NO，ET含量的变化与肠源性LPS血症发生密切相关.

    [关键词] 胆管阻塞，肝外;内毒素类;血液动力学;内皮素类;大鼠

    Effects of endotoxin content on change of hemodynamics of gut mucosa in obstructive jaundice in rats

    JIANG Xian 1 ，LI Ming-zhi 2 ，JIANG Xu 3 ，SHEN Rong-shuo 3

    (1.Department of Otorhinolaryngology，Affiliated Hospital of Yanbian University;2.Health Supervisimon Section of Public Health Bureau in Yanji City;3.Department of General Surgery ......