摘要:目的 比较ACL-7000血凝仪测定纤维蛋白原的2种方法和探讨其临床应用。 方法 ACL-7000血凝仪的Von Clauss法和PT-der法分别检测不同纤维蛋白原含量的病人血浆。 结果 纤维蛋白原小于2.00g/L或在2.00～4.00g/L之间，2种方法没有差异显著性(P>0.05)，纤维蛋白原大于4.00g/L时，PT-der法所得结果明显高于Von Clauss法(P<0.02)。 结论 纤维蛋白原小于2.00g/L或在2.00～4.00g/L之间时，可以使用PT-der法替代Von Clauss法检测纤维蛋白原;纤维蛋白原大于4.00g/L时，不能用PT-der法替代Von Clauss法。因此，在临床工作中，应根据疾病的需要及纤维蛋白原的含量，选择不同的检测方法。

    关键词:纤维蛋白原;Von Clauss法;PT-der法

    Comparison of methodology in determination of fibrigen by using ACL-7000coagulatometer and clinical application.

    HUANG Tao，PAN Hong，PENG Xiao-ming，et al.

    (Hainan Provincial People's Hospital，Haikou570311Hainan，P.R.China)

    Abstract:Objective To compare two different methods of fibrinogen detection and explore its clinical application. Methods To detect different level fibrinogen by Von Clauss method and PT-derived method with ACL-7000Coagulation system. Results There is no significantly statistical difference(P>0.05)when the level of fibrinogen is lower than2g/L or between2g/L and4g/L.There is significantly statistical defference(P<0.02)when the level of fibrinogen is higher than4g/L.Result of PT-derived method is significantly higher than it of Von Clauss method. Conclusion PT-derived method may replace Von Clauss in the fib-rinogen detection when the level of fibrinogen is lower than2g/L or between2g/L and4g/L.Fibrinogen is detected with Von Clauss method when the level of fibrinogen is higher than4g/L. ......