[摘要]目的 探讨子痫前期病人血清抑制素A和激活素A的水平变化及其与病情的关系。方法 采用酶联免疫分析法(ELISA)，检测了40例子痫前期病人(子痫前期组，包括轻度20例，重度20例)及40例正常妊娠妇女(正常妊娠组)的血清抑制素A和激活素A水平。结果 子痫前期组病人血清抑制素A、激活素A水平均高于正常妊娠组，差异有统计学意义( t=69.93、30.12，P <0.01);其中重度子痫前期病人血清抑制素A、激活素A水平高于轻度子痫前期病人，差异有统计学意义( t=43.88、18.84，P <0.01)。两组病人血清抑制素A与激活素A水平呈正相关( r=0.59、0.52，P <0.01);子痫前期组病人血清抑制素A、激活素A水平与24 h尿蛋白含量呈显著正相关( r=0.76、0.56，P <0.01)。重度子痫前期伴胎儿生长受限(FGR)与不伴FGR病人血清抑制素A、激活素A水平差异无统计学意义( P >0.05)。结论 子痫前期病人血清抑制素A、激活素A水平较正常妊娠妇女显著升高，且与子痫前期病情进展关系密切。

    [关键词] 子痫;抑制素类;激活素类

    RELATIONSHIP BETWEEN SERUM INHIBIN A AND ACTIVIN A CONCENTRATIONS AND PREECLAMPSIA

    WANG LIN， LIU QUN-YING， YE YUAN-HUA， et al

    (Department of Obstetrics， The Second Affiliated Hospital of Qingdao University Medical College， Qingdao 266003，China)

    [ABSTRACT]ObjectiveTo investigate whether inhibin A and activin A serum levels are altered in women with preeclamp-sia. MethodsSerum samples of 40 women with preeclampsia (study group， 20 patients with mild preeclampsia and another 20 with severe preeclampsia) and 40 normal pregnant women (control group) were assayed for inhibin A and activin A by specific en-zyme-linked immunosorbent assay (ELISA). ResultsThe serum concentrations of inhibin A and activin A were significantly higher in the study group than in the control group ( t=69.93 ......