[摘要]目的 观察冠心病(CHD)病人血浆细胞间黏附分子-1水平的变化，并探讨其与冠心病活动性之间的关系。方法 采用酶联免疫吸附(ELISA)法，检测了60例CHD病人血浆可溶性细胞间黏附分子-1(sICAM-1)的水平，并与健康对照组进行比较。结果 CHD病人血浆sICAM-1水平高于对照组( t=7.136，P < 0.01 );且急性心肌梗死(AMI)病人显著高于陈旧性心肌梗死病人及稳定型心绞痛(SA)病人( t=4.329、5.635 ，P <0.01)，不稳定型心绞痛(UAP)病人高于SA病人( t=3.666，P <0.01)。结论 CHD病人sICAM-1水平明显高于正常对照组，且在一定程度上反映了病情的严重程度。

    [关键词] 冠状动脉疾病;细胞黏附分子;酶联免疫吸附测定

    CHANGES OF INTERCELLULAR ADHESION MOLECULE-1 IN PATIENTS WITH CORONARY HEART DISEASE

    TIAN JING-HUI， LIU CHENG-YU， LI DONG， et al

    (Department of Medical Laboratory， Taishan Medical College， Taian 271000，China)

    [ABSTRACT]ObjectiveTo explore the changes of intercellular adhesion molecule-1 (ICAM-1) in patients with coronary heart disease (CHD) and to evaluate its clinical relation to CHD. MethodsPlasma ICAM-1 was detected by enzyme-linked im-munosorbent assay (ELISA) in 60 patients with CHD. The results were compared with those of the healthy subjects. Results Plasma sICAM-1 was significantly elevated in patients with CHD and differed significantly from that of the control group ( t= 7.136 ......