[摘 要]目的: 探讨原发性双侧乳腺癌的临床特征、治疗和预后。 方法: 回顾了我院2002年1月～2006年3月经病理组织学证实的12例原发性双侧乳腺癌患者的临床资料，结合文献复习对原发性双侧乳腺癌的诊断标准、发病率、病因及危险因素、治疗方式及预后进行讨论。结果: 12例均符合原发性双侧乳腺癌的诊断标准，同时性2例，异时性10例，4例(33.3%)有家族史，第一癌发病年龄较轻，绝经前9例(75%)，病理类型以浸润性导管癌和特殊类型为主，有4例(33.3%)ER、HER2、p53基因表达水平有差异，首发侧病期亦较早，经综合治疗后目前生存情况良好。 结 论: 应重视双侧乳腺癌的发生，单侧乳腺癌发生后应积极随访以早期发现对侧病变，并采取综合治疗措施。

    [关键词] 双侧乳腺癌; 原发性; 诊断; 治疗

    Diagnosis and Treatment of bilateral primary breast cancer

    ZHENG Lin ， WANG Jie

    (Department of General surgery， the Second People′s Hospital of Changzhou，Affliated Nanjing Medical University， Changzhou Jiangsu 213003， China)

    [Abstract] Objective: To study the characteristics，treatment and the prognosis of bilateral primary breast cancer(BPBC). Methods: Twelve cases of BPBC patients underwent radical mastectomy from Janu- ary 2002 to March 2006 in our unit were retrospectively analyzed.To evaluate diagnosis，incidence， etiolo- gy， risk factors， treatment and prognosis. Results: Twelve cases all confirmed with BPBC， induding 2 presented simultaneous bilateral tumors and 10 developed bilateral breast cancer with interval in between. Four cases belonged to kindred breast cancer. Nine cases(75%) got it before menopause as the age of pa- tients suffering from the first breast cancer was trending younger. Pathological types of 12 cases were mostly invasive ductal carcinoma or special types. The expressions of ER ......