[摘 要] 目的: 了解β-胡萝卜素对腹腔注射Con A诱导昆明鼠肝纤维化有无预防作用。方法: 30只Balb/c鼠随机分组:对照组10只 ，PBS腹腔注射、生理盐水灌胃。未预防组 10只，腹腔注射Con A、生理盐水灌胃8周。预防组10只，Con A腹腔注射、β-胡萝卜素灌胃。第9周处死所有小鼠，测血清ALT、AST，肝组织病理检查。 结果: 未预防组有典型肝纤维化;对照组与预防组未出现肝纤维化。 结论: β-胡萝卜素对肝纤维化有预防作用。

    [关键词] 刀豆蛋白A; 肝纤维化; 动物模型; β-胡萝卜素

    Preventative effect of β-carotene on hepatic fibrosis

    ZHANG Wei， ZHU Li-qun

    (Department of Gastroenterology，the Affiliated Hospital of Jangsu University， Zhenjiang Jiangsu 212001，China)

    [Abstract] Objective: To detect preventative effect of β-carotene on hepatic fibrosis in Balb/c mice in- duced by repeatedly administered concanavalin A. Methods: Thirty Balb/c mice were divided into different three groups. Control group ......