蒙古沙鼠幽门螺杆菌相关性胃炎Sonic hedgehog基因、IL-1β及TNF-α的表达
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李忠武, 刘鲁英, 田萌萌, 游伟程, 李吉友
幽门螺杆菌;Sonichedgehog基因;白细胞介素-1β;肿瘤坏死因子-a;萎缩性胃炎,蒙古沙鼠幽门螺杆菌相关性胃炎Sonichedgehog基因、IL-1β及TNF-α的表达,李忠武,刘鲁英,田萌萌,李吉友,游伟程,李忠武,通讯作者:,ExpressionofSonichedgeh
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李忠武, 刘鲁英, 田萌萌, 李吉友, 北京肿瘤医院病理科, 北京大学临床肿瘤学院 北京市 100036
游伟程, 北京市肿瘤防治研究所流行病学研究室, 北京大学临床肿瘤学院 北京市 100036
李忠武, 医学博士, 主要从事胃癌及胃癌癌前病变研究.
国家基础研究973项目, No. 1998051203
通讯作者: 李吉友, 100036, 北京市海淀区阜成路52号, 北京肿瘤医院病理科, 北京大学临床肿瘤学院. lijiyou@263.net
电话: 010-88196331
收稿日期: 2006-10-08 接受日期: 2006-10-25
Expression of Sonic hedgehog gene, interleukin-1β, tumor necrosis factor-α in gastric epithelium of mongolian gerbils after H pylori inoculation
Zhong-Wu Li, Lu-Ying Liu, Meng-Meng Tian, Wei-Cheng You, Ji-You Li
Zhong-Wu Li, Lu-Ying Liu, Meng-Meng Tian, Ji-You Li,Department of Pathology, Beijing Cancer Hospital; Peking University School of Oncology, Beijing 100036, China
Wei-Cheng You, Department of Epidemiology,Institute of Tumor Prevention and Therapy; Peking University School of Oncology, Beijing 100036, China
Supported bythe National Basic Research Priorities Program (973 Program), No. 1998051203
Correspondence to:Ji-You Li, Department of Pathology, Beijing Cancer Hospital; Peking University School of Oncology, Beijing 100036, China. lijiyou@263.net
Received:2006-10-08 Accepted:2006-10-25
Abstract
AIM: To investigate the expression of morphogene Sonic hedgehog (Shh), interleukin-1β (IL-1β), tumor necrosis factor-a (TNF-a) in gastric epithelium of mongolian gerbils after H pylori inoculation and their correlations with the pathologic changes of Helicobacter pylori related gastritis.
METHODS: A total of 50 male mongolian gerbils were inoculated with H pylori and another 50 gerbils served as controls. The levels of Shh, IL-1β and TNF-a mRNA expression were detected by reverse transcription-polymerase chain reaction (RT-PCR), and the level of Shh protein expression was examined by immunohistochemistry 4, 12, 24, 36 and 48 weeks after inoculation.
RESULTS: As compared with those in the controls, both the expression levels of Shh mRNA and protein were decreased significantly at the 36th (t = 3 ......
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