进展期大肠癌患者术中应用化疗药物外周血CEA、CA19-9的检测及临床意义
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杨茂鹏, 于洪亮, 王夫景, 黄跃南, 杨维良
大肠癌;术中化疗;癌胚抗原;糖类抗原19-9,杨茂鹏,于洪亮,王夫景,黄跃南,杨维良,通讯作者:,Detectionofserumcarcinoembryonicantigenandcarbohydrateantigen
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杨茂鹏, 于洪亮, 王夫景, 黄跃南, 杨维良, 哈尔滨医科大学第二临床附属医学院普外三科 黑龙江省哈尔滨市 150086
通讯作者: 王夫景, 150086, 黑龙江省哈尔滨市, 哈尔滨医科大学第二临床附属医学院普外三科. yangmaopeng_yd2@163.com
电话: 0451-86605575
收稿日期: 2006-10-22 接受日期: 2006-11-02
Detection of serum carcinoembryonic antigen and carbohydrate antigen 19-9 in patients with progressive colon cancer and its clinical significance
Mao-Peng Yang, Hong-Liang Yu, Fu-Jing Wang, Yue-Nan Huang, Wei-Liang Yang
Mao-Peng Yang, Hong-Liang Yu, Fu-Jing Wang, Yue-Nan Huang, Wei-Liang Yang,the Third Department of General Surgery, the Second Hospital of Harbin Medical University, Harbin 150086, China
Correspondence to:Fu-Jing Wang, the Third Department of General Surgery, the Second Hospital of Harbin Medical University, Harbin 150086, China. yangmaopeng_yd2@163.com
Received:2006-10-22 Accepted:2006-11-02
Abstract
AIM: To observe the pre- and post-operational changes of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in patients with progressive colon cancer and their clinical significances.
METHODS: The serum levels of CEA and CA19-9 were detected by indirect enzyme-linked immunosorbent assay (ELISA) in 60 patients (30 cases received chemotherapy during operation while 30 cases did not) diagnosed with colon cancer and 30 normal volunteers.
RESULTS: The serum levels of CEA and CA19-9 were significantly higher in all the cancer patients before operation than those in the normal controls (60.73 ± 25.99 mg/L vs 2.67 ± 1.643 mg/L, P < 0.01; 112.73 ± 78.76 kU/L vs 14.6 ± 6.68 kU/L, P < 0.01). CEA and CA19-9 levels were rapidly decreased in the patients received chemotherapy (7 d post-operation: 7.96 ± 3.32 mg/L, 29.34 ± 11.05 kU/L, P < 0.01 vs pre-operation), but they were not significantly decreased in the patients without chemotherapy (7 d: post-operation: 34.23 ± 20.59 mg/L, 88.12 ± 32.28 kU/L, P > 0.05vs pre-operation) ......
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